3D Human Retinal Pigment Epithelial Spheroid Model Introduction

The 3D Human Retinal Pigment Epithelial (RPE) spheroid model is an advanced in vitro system used for the study of various ocular diseases and drug screening. Creative Biolabs offers highly customizable 3D Human RPE spheroid models, aiming at facilitating the advancement of your preclinical drug discovery initiatives.

About 3D Human RPE Spheroid Model

The retina is a thin (∼0.25 mm) layer of neurons in the back of the eyeball. The RPE plays a crucial role in supporting retinal ganglion cells and contributes to light detection in all animal species, along with photoreceptor cells. Its main function is to provide support to the photoreceptor cells and maintain their health and function.

Fig 1. Schematic diagram of eye organoids.¹

Multicellular spheroids of human RPE cells were previously shown to form drusen, a biomarker of age-related macular degeneration (AMD). The current study confirmed that drusen originate from the RPE and demonstrated that the 3D culture system could be used as an in vitro model for studying drusen biogenesis and AMD pathogenesis. RPE spheroid models can also be applied in investigating therapies for retinal degeneration, retinal implants, gene therapies, drug screening, and more.

What Can We Provide?

Characterization

Creative Biolabs provides comprehensive characterization and analysis of the 3D human RPE spheroids to evaluate their structural and functional integrity. We offer a range of assays, including viability assays, histological analysis, and gene expression profiling.

Disease Modeling & Drug Screening

Creative Biolabs' 3D human RPE spheroid model can be used to model various ocular diseases, such as AMD and retinitis pigmentosa, and to evaluate the efficacy of potential drugs.

Toxicology Testing

We offer toxicity testing services using the 3D human RPE spheroid model to evaluate the safety and potential adverse effects of various compounds. We can help our customers to identify potential safety issues before a drug candidate is tested in animal models or humans.

Preclinical Studies

Our 3D human RPE spheroid model presents an excellent option for conducting preclinical studies, making it an invaluable resource for biomarker discovery and target analysis/validation to accelerate and enhance the efficacy of preclinical research.

Why Choose Us?

Creative Biolabs’s 3D human RPE spheroid models allow the construction of a well-differentiated monolayer of RPE with a Bruch’s membrane, which more closely mimics the in vivo environment than traditional 2D cultures. We have an extensive spheroid bank, and our team can generate spheroids using a variety of cell sources and culture conditions, allowing greater flexibility and customization. In addition to RPE Spheroid Models, you may also be interested in:

Related Services

Our scientists specialized in the 3D biology field are equipped to fulfill a wide range of client needs, with customized solutions that precisely align with their unique demands. These solutions are strengthened by a comprehensive suite of 3D biology-based assay services, enabling us to effectively address your specific requirements. If you're seeking 3D biology models, we encourage you to contact us without hesitation.

Reference

Lieto, K.; et al. Looking into the eyes – in vitro models for ocular research. Int. Mol. Sci. 2022, 23(16): 9158.

Research Model

3D Biology Based Biomarker Discovery

3D Biology Based Drug Discovery and Development

3D Biology Based Toxicity Evaluation

Supporting Assays

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