Disease-on-a-Chip Model Introduction

At Creative Biolabs, we specialize in delivering exceptional disease-on-a-chip models and comprehensive services. Our state-of-the-art organ chips have transformed the landscape of biomedical research, offering precise and reliable platforms to study human organs in a controlled environment.

Disease-on-a-chip Model

The organ-on-a-chip is a microfluidic cell culture device manufactured through microchip fabrication methods. This device typically consists of interconnected perfusion chambers with multi-cellular layers, tissue interfaces, physicochemical microenvironments, and a simulated human vascular system. Organ-on-chip platforms for modeling human diseases are widely recognized as cell culture microengineering devices capable of accurately reflecting human physiology and human-relevant responses to pathogens. They offer an unparalleled opportunity to bridge the gap between in vitro experimental models and in vivo human pathophysiology, making them a highly promising platform for disease studies and development of effective therapeutics.

Fig 1. Organ-on-chips for disease research. (Ingber, 2022)

Traditional Disease Research Models

Traditional disease research models often involve immortalized cell lines cultured in 2D environments or experimental animal models. However, these simplified cell culture models completely overlook the exchange of metabolites between cells and the transfer of chemical substances such as hormones and immune modulators. Animal data often fail to predict results in human clinical trials and are typically costly and labor-intensive. In fact, nearly 90% of drugs fail in clinical trials despite passing animal testing. The lack of effective disease models leads to rising healthcare costs and a decrease in the availability of effective drugs for patients.

Fig 2. Disease-on-chip. (Ingber, 2022)

Advantages of Our Disease-on-a-chip Model

Disease-on-a-chip provides researchers with cost-effective and measurable improvements in research benefits, particularly in disease modeling. In comparison to complex, challenging, and ethically problematic animal models, our disease chips offer irreplaceable advantages:

• High Fidelity: Disease chips contain human cells cultured under fluid flow, allowing for highly faithful reproduction of organ-level pathophysiology.
• High Versatility: Disease chips have been extensively used to model even the most complex diseases or rare genetic disorders, faithfully reproducing clinical responses to drugs, radiation, toxins, and infectious pathogens.
• Dynamic Environment: Disease chips can be configured as dynamic culture systems, including the modulation of oxygen concentration, drug concentration, or toxin gradients to better mimic disease progression.
• Multi-Organ Systems: Coupled multi-organ chips enable the modeling of diseases involving complex systemic physiological responses.

What We Provide?

Our disease chips, based on soft lithography, have been successfully utilized for simulating various complex disease types. These models authentically reflect the anticipated drug responses or toxicities within the human body, making them highly applicable to a wide range of disease and drug-related studies.

Related Services

Creative Biolabs' unwavering commitment to quality, innovation, and customer satisfaction ensures that you have the tools and support you need to make groundbreaking advancements. Please do not hesitate to contact us to gain deeper insights into our highly customizable disease-on-a-chip models and the supporting services listed below. Join the ranks of pioneering scientists who have harnessed the power of our 3D models to accelerate your preclinical drug discovery research.

Related Sections:

• Single Organ-on-a-Chip Model Introduction
• Multiple Organs-on-a-Chip Model Introduction
• Barrier Tissue On-a-Chip Model Introduction
• Customized Tissue-on-a-Chip Model Introduction