3D Biology Based Cardiotoxicity Evaluation Services

Due to complex disease mechanisms, high degree of individualization, lack of evaluation indicators, limitations of animal models, unpredictable side effects, and high research costs, cardiovascular drug development is facing many challenges and risks. Although traditional two-dimension (2D) cell culture and animal models can test certain aspects of cardiovascular toxicity, they often cannot fully reflect the real situation in vivo. The three-dimension (3D) model can more realistically simulate complex environments such as cell interactions, cell-cell, and cell-matrix interactions in human tissues, thereby more accurately evaluating cardiovascular toxicity. Creative Biolabs provides this more accurate 3D model-based cardiovascular toxicity assessment service.

Fig.1 Main advantages and limitations of available models for use in cardiotoxicity studies and new drug development.1

3D Biology Based Cardiovascular Toxicity Evaluation Is Necessary

Cardiovascular toxicity evaluation based on 3D biology is to evaluate and detect the adverse reactions of drugs in the human cardiovascular system. This is an essential part of the new drug development process. Its necessity is mainly reflected in the following aspects.

Replace animal experiments	3D models can be used for high-throughput drug screening and cardiovascular toxicity evaluation, effectively reducing the number and cost of animal experiments, while avoiding ethical restrictions.
Enhance drug development efficiency	Cardiovascular toxicity evaluation is helpful for the early detection of adverse drug reactions. It enables timely resolution of research issues, thereby eliminating unnecessary time and financial costs.
Improve the success rate of new drugs on the market	Reducing the risk of adverse reactions or cardiovascular events in patients helps to ensure the safety and efficacy of new drugs, which in turn can boost the success rate of new drug market approvals.

What indicators can be detected in 3D cardiovascular models?

Cell viability
Oxidative stress damage
Mitochondrial function
Cardiovascular dynamic parameters
Cardiovascular function-related biochemical markers
Myocardial contractility
Cell membrane potential assay
Intercellular calcium transport assay
Other possible tests

3D Cardiovascular Model Summary for Cardiovascular Toxicity Evaluation at Creative Biolabs

Creative Biolabs provides customers with a variety of 3D cardiovascular models for evaluating the potential cardiovascular toxicity of candidate drugs.

Cardiotoxicity Evaluation by Cardiac Organoid Model

Cardiotoxicity Evaluation by Precision-Cut Human Heart Slice Model

Cardiotoxicity Evaluation by 3D Cardiac Spheroid Model

Cardiotoxicity Evaluation by Ex vivo Human Cardiovascular Tissue Model

Cardiotoxicity Evaluation by iPSC-derived Cardiomyocytes

hERG Safety Evaluation

We have advanced technology and equipment to ensure the high quality and stability of these models. Also, we have an experienced scientific research team, which can provide customers with reliable experimental data and professional data analysis. Most importantly, we provide the most comprehensive cardiovascular toxicity evaluation service, which help customers expedite their research in a cost-effective way. If you have been searching for suitable 3D cardiovascular models to test the safety of your drug candidates, please do not hesitate to contact us.

Reference

Andrysiak, K.; et al. Human-induced pluripotent stem cell-derived cardiomyocytes, 3D cardiac structures, and heart-on-a-chip as tools for drug research. Pflugers Archiv-European Journal of Physiology. 2021, 473(7):1061-1085.

Research Model

3D Biology Based Biomarker Discovery

3D Biology Based Drug Discovery and Development

3D Biology Based Toxicity Evaluation

Supporting Assays

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