3D Human Airway Spheroid Model Introduction

The airway epithelium plays a critical role as the first line of defense against inhaled pathogens and toxic substances in the lungs. Therefore, primary bronchial epithelial cells serve as an excellent in vitro source for studying airway diseases. Creative Biolabs unequivocally offers the 3D human airway spheroid model, which will help your preclinical drug discovery projects achieve rapid progress with high quality and easy access.

3D spheroid structures transduction. (Castillon, et al., 2004)

Traditional Models for Respiratory Research

The optimal results obtained by human cells, when cultured in 2D, are typically limited to the initial number of cells that can be isolated, which restricts the study of disease progression and onset to a typical late-stage disease state. On the other hand, the translation of research findings from animal models to clinical applications for human use has proven to be a complex task, for animal models may not fully capture the entire disease onset or progression as observed in humans.

What We Provide

The 3D environment plays a crucial role in studying physiological, pathophysiological, and immunomodulatory responses against various respiratory conditions. Creative Biolabs offers airway spheroids composed of primary bronchial epithelial cells, which accurately replicate disease phenotypes observed in humans. Through rigorous analyses, we have confirmed the presence of basal cells, ciliated cells, and goblet cells within the spheroids, maintaining their polarization and differentiation states over extended periods.

Key Features

Our 3D human airway spheroid model offers state-of-the-art solutions for respiratory research and drug development with irreplaceable advantages.

3D Human Airway Spheroid Model Introduction

By leveraging the power of 3D cell culture technology, we enable more accurate, efficient, and ethically advanced studies of the human airway system. Creative Biolabs’s 3D human spheroid models promise to be the next frontier of disease research, with the ability to translate to clinical trials, and promote cell–cell interactions as seen in vivo. In addition to 3D human airway spheroid model, you may also be interested in the following 3D human spheroid models:

Related Services

At Creative Biolabs, our primary aim is to bolster your research pursuits through the delivery of an expansive and all-encompassing range of pertinent services. Contact us today and our experts will be happy to discuss your specific requirements, provide detailed information, and assist you in designing a customized service plan to meet your research goals.

Reference

Castilon, N.; et al. Regeneration of a well-differentiated human airway surface epithelium by spheroid and lentivirus vector-transduced airway cells. Journal of Gene Medicine. 2004, 6: 846-856.

Research Model

3D Biology Based Biomarker Discovery

3D Biology Based Drug Discovery and Development

3D Biology Based Toxicity Evaluation

Supporting Assays

3D Human Airway Spheroid Model Introduction

Traditional Models for Respiratory Research

What We Provide

Key Features

Related Services

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