Creative Biolabs is a pioneering biotechnology company committed to providing cutting-edge customized tissue-on-a-chip models and related services. Our advanced tissue-on-a-chip model represents a revolutionary leap in biomedical research, accurately recreating human organ functionalities for enhanced drug discovery and toxicity testing.
Tissue-on-a-chip model is an advanced integration of cutting-edge techniques. It enables the construction of organ and disease-specific micro-physiological systems in vitro, accurately mimicking the key structural and functional characteristics of various human tissues and organs, as well as the intricate interconnections between them. These tissue-on-chip systems are designed to predict human responses to drugs or different external stimuli.
Due to the lack of cellular communication within or between organs, conventional in vitro human cell models often provide incomplete and context-limited assessments of human responses.
Furthermore, numerous studies have demonstrated that animal research often fails to predict human outcomes. Drugs validated in various animal models have either shown inefficacy or induced potentially life-threatening toxicities in subsequent clinical trials. In fact, researchers are unable to accurately predict whether a drug that is excluded during early-stage experiments is safe and effective for humans.
Tissue-on-a-chip offers more accurate and effective drug testing data compared to traditional 2D static cultures and animal models. Utilizing tissue-on-a-chip systems for preclinical drug screening allows for the early detection of potential drug efficacy and side effects. In contrast to labor-intensive and uncontrollable animal models, tissue-on-a-chip platforms exhibit high throughput, safety, and require low sample volumes. They provide irreplaceable advantages in drug screening and development, absorption and metabolism studies, and creating artificial biomimetic microenvironments.
Table 1 The differences between different research models. (Creative Biolabs)
2D Cell Culture | Animal Testing | 3D Cell Culture | Single OOC Models | Multi-OOC Models | |
Human Relevance | √ | × | √√ | √√ | √√√ |
Physiological Configuration | × | √√√ | √ | √√ | √√ |
Physiological Integrity | × | √√√ | √ | √ | √√ |
Low Sample Volume | √ | × | √ | √ | √ |
Pharmacokinetics | × | √ | × | × | √ |
High-Throughput Screening | √ | × | √ | √ | √ |
Application Difficulty | ⭐ | ⭐⭐⭐ | ⭐⭐ | ⭐⭐ | ⭐⭐ |
Fig 1. Multi-organ-on-chip models. (Ingber, 2022)
The greatest characteristic and advantage of tissue-on-a-chip lies in its customizability. Chips constructed rapidly through soft lithography can be highly tailored to meet any desired specifications. Our professional team of engineers is always ready to fulfill your every requirement. From structural and functional aspects to size, materials, surface modifications, membrane types, and simulation of specific diseases or organ types, as well as multi-organ systems, our experts are dedicated to providing you with the finest solutions based on your needs.
Choose excellence and unlock the full potential of your research with Creative Biolabs' exceptional tissue-on-a-chip products and services. Our dedicated team of experts is committed to providing cutting-edge solutions tailored to your needs. By partnering with us, you gain access to innovative technologies, reliable support, and a trusted collaboration that propels your scientific endeavors forward. With our extensive expertise and unwavering commitment, we are confident in our ability to help you achieve your research goals. Please contact us at your convenience to learn more about our highly customizable models and a detailed quote.
At Creative Biolabs, we uphold a customer-centric ethos, recognizing the uniqueness of each project, and aspiring to establish ourselves as your preferred partner. Whether your focus lies on customized organ-on-a-chip models or you're interested to explore the spectrum of our 3D biology-based services, we extend an open invitation to contact us to explore more possibilities.
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