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3D Human Chondrocyte-Articular Spheroid Model Introduction

Articular chondrocytes, residing within cartilage, are known to be phenotypically unstable in culture and technically difficult for in vitro research due to their sensitivity and susceptibility to changes in the complex extracellular matrix. Overcoming these hurdles, Creative Biolabs proudly provide a stable 3D human chondrocyte-articular spheroid model for its study and drug development.

About 3D Human Chondrocyte-Articular Spheroid Model

Human Chondrocytes (HC) are derived from normal human articular cartilage, where they produce and maintain the extracellular matrix of cartilage, including type II collagen. Articular chondrocytes are cells responsible for the unique features of articular cartilage, which are used widely in research for that they are a gold standard control for cellular reprogramming and differentiation. According to its characteristics, it would appear appropriate to use truly committed chondrocytes to engineer in vitro or in vivo cartilage to repair a cartilaginous defect.

Schematic illustrations of (A) cartilage composition and typical tissue zones and (B) the tissue engineering approach for cartilage repair. (Kresanti, et al., 2021) Fig 1. Schematic illustrations of (A) cartilage composition and typical tissue zones and (B) the tissue engineering approach for cartilage repair.1

Advantages of Us

Advantages 1

Our 3D Human Chondrocyte-Articular Spheroid Model can generate scaffolds with spatial variation of cell distribution or mechanical properties, built with a variety of materials that can mimic complex tissue architecture.

Advantages 2

A serious limiting factor is that the primary cell type in cartilage, the articular chondrocyte, tends to de-differentiate when grown on 2D surfaces for in vitro expansion. Our 3D Spheroid Models have been developed and used to counter this loss of chondrogenic capabilities and a higher rate of dedifferentiation can be generally observed.

Advantages 3

Our lab's rich research experience in 3D Modeling provides an optimal microenvironment for more stable maintenance of the chondrocyte phenotype, thereby highlighting a fair balance between proliferation and differentiation.

Backed by an extensive spheroid library, our scientific team excels in generating spheroids from diverse cell sources and culture conditions, ensuring that we are poised to contribute significantly to the success of your drug discovery project. In addition to 3D Human Chondrocyte-Articular Spheroid Models, you may also be interested in:

Related Services

Expanding beyond our diverse portfolio of 3D spheroid models, Creative Biolabs extends its expertise to encompass a range of professional technical services precisely crafted to meet the varied demands of research. We invite you to connect with us to delve into the world of our highly customizable models and obtain a tailored quote.

Reference

  1. Kresanti, N.; et al. Biomimetic hydrogels designed for cartilage tissue engineering. Front. BiomaterSci. 2021, 9, 4246-4259.
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