3D Hepatic Stellate-Endothelial Cell Spheroid Model Introduction

Liver fibrosis represent pressing healthcare concerns globally, carrying significant importance due to their potential to progress into life-threatening conditions like cirrhosis and hepatocellular carcinoma. At Creative Biolabs, we unequivocally introduce our exceptional 3D hepatic stellate-endothelial cell (HSEC) spheroid model, a revolutionary approach for your research endeavors.

Limitations of Conventional Models for Liver Fibrosis

Commonly used 2D liver cell monocultures or co-cultures in vitro liver models do not sufficiently represent the complexity of the human liver’s structure and function, leading to less reliable evaluation results. While traditional animal models have provided valuable insights into liver fibrosis research, they fall short in mirroring human patients due to notable dissimilarities in nutritional metabolism and disease-related gene regulation during the pathological course. Additionally, the relatively short lifespan of experimental animals often leads researchers to induce liver fibrosis modeling using highly hepatotoxic agents, which raises significant ethical concerns.

Histological examination of 3D primary human cell‑based spheroids. (Strobel, et al., 2021)

Why Choose 3D Hepatic Stellate-Endothelial Cell Spheroid Model?

3D HSEC co-culture spheroid models offer heightened predictability of drug response in humans and have been widely employed in many studies to forecast the in vivo metabolism and clearance of new therapeutics. Creative Biolabs’ human HSEC spheroid is a characterized liver fibrosis model constructed by co-seeding hepatic stellate cells and endothelial cells in a fixed proportion. This alternative approach reflects the complex microenvironment and pathological processes involved in liver fibrosis, making it suitable for screening and improving candidate anti-fibrotic molecules.

Hepatic stellate cell spheroids for tumor research. (Song, et al., 2016)

What We Provide?

Elevating your research possibilities, Creative Biolabs introduces a breakthrough with our 3D HSEC spheroid models, designed to recreate the complex interaction between hepatic stellate cells and endothelial cells in a co-culture setting. Our model is characterized by the following strengths, ensuring comprehensive support for your research endeavors.

3D Hepatic Stellate-Endothelial Cell Spheroid Model Introduction

As a premier biotechnology company, we are committed to delivering the highest standards of quality and innovation. We proudly present a series of human spheroid models, empowering you with unparalleled adaptability and bespoke solutions to explore disease research and pioneer new drug development with advanced precision.

Related Services

Building upon our expansive range of 3D spheroid models, Creative Biolabs is devoted to providing high-quality preclinical drug discovery services using listed as follows to our global customers. We invite you to contact us to explore the possibilities of collaboration and how our groundbreaking 3D human spheroid model can contribute to your research endeavors.

References

Strobel, S.; et al. A 3D primary human cell‑based in vitro model of non‑alcoholic steatohepatitis for efcacy testing of clinical drug candidates. Nature. 2021, 11: 22765.
Song, Y.; et al. Activated hepatic stellate cells play pivotal roles in hepatocellular carcinoma cell chemoresistance and migration in multicellular tumor spheroids. Nature. 2016, 6: 36750.

Research Model

3D Biology Based Biomarker Discovery

3D Biology Based Drug Discovery and Development

3D Biology Based Toxicity Evaluation

Supporting Assays

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