3D Biology Based Toxicity Evaluation Services

At Creative Biolabs, we recognize the criticality of assessing the toxicity of substances on living organisms. Our team of experts offers a comprehensive suite of 3D biology-based toxicity evaluation services that are fully customizable to your specific requirements.

3D spheroid morphology. (Tutty, 2022)

Traditional Toxicity Evaluation Models

Toxicity evaluation is a critical aspect of biology that involves assessing the adverse effects of substances on living organisms. While analyzing specific cell lines through in vitro culturing is a simple and effective method, common 2D cell cultures fall short in fully representing the functions of 3D tissues and their complex cell-cell and cell-matrix interactions. This is due to significant differences in the diffusion and transport of molecules and cell signals. Although animal models have significantly improved our biological understanding, they often exhibit traits in toxicology that differ from those in humans. This poses a challenge, as molecules that are harmless to animals may exhibit strong toxicity during clinical testing.

3D Biology-Based Toxicity Evaluation

To overcome these limitations, the use of 3D biological models is a promising approach to evaluate toxicity more accurately in preclinical stage. Compared to 2D cultures, 3D models offer superior tissue/organ structure, cell differentiation ability, proliferation, drug toxicity, and metabolism. Consequently, the results obtained from these models are closer to those obtained in vivo. As a result, 3D models accelerate target identification in preclinical research and provide additional reliability and practicality for toxicity assessment. The use of 3D models also significantly reduces experimental costs and time while avoiding related ethical and moral issues associated with animal testing.

Hepatic 3D spheroid model for toxicity evaluation. (Hendriks, 2016)

What do We Provide?

Our testing projects span a broad range of fields, including nanomaterials, drugs, compounds, biologics, and microbial pathogens. We are unwavering in our commitment to providing unparalleled technical support, safety guidance, and precise predictive effectiveness at every stage of your research. Count on us to cater to your toxicity evaluation needs with utmost dedication and professionalism.

Our Services

Creative Biolabs is thrilled to announce the launch of our latest 3D biology-based toxicity evaluation service. Our team of highly skilled scientists and advanced technology enables us to deliver precise and dependable results while implementing strict quality control measures. We take pride in providing comprehensive and complete assays, surpassing industry standards. Our fully 3D-based biology assay services eliminate any potential for error, providing you with the utmost specificity, accuracy, precision, sensitivity, and reproducibility in a cost-effective way.

Our experts guarantee complete, optimized and reproducible data references and reports after each test, giving you the confidence to make informed decisions. Choose Creative Biolabs for your biological analysis needs and let us take your research to the next level.

References

Tutty, M.A.; et al. Pre‑clinical 2D and 3D toxicity response to a panel of nanomaterials; comparative assessment of NBM‑induced liver toxicity. Drug Delivery and Translational Research. 2022, 12: 2157-2177.
Hendriks, F.G.; et al. Hepatic 3D spheroid models for the detection and study of compounds with cholestatic liability. Nature. 2016, 6: 35434.

Research Model

3D Biology Based Biomarker Discovery

3D Biology Based Drug Discovery and Development

3D Biology Based Toxicity Evaluation

Supporting Assays

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Research Model

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