3D Normal Organoid Model

As a reputable biological company, Creative Biolabs is dedicated to establishing reliable 3D organoid models to accelerate your scientific research on multiple diseases. 3D normal organoid models are one of our featured products, which can be flexibly customized to meet your diversified research needs.

Construction of 3D Normal Organoid Models

In recent decades, as organoid technology develops rapidly, 3D normal organoid models have been constructed from embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs), and adult stem cells by utilizing different cell isolation operations and growth factor combinations. The donor tissues are healthy and mainly include the pancreas, stomach, colon, small intestine, and so on.

Fig 1 The establishment of normal organoids. (Xu, 2018)

Advantages of 3D Normal Organoid Models

As an emerging ex vivo model, 3D normal organoids offer the tool ensuring the implementation of aiming at tumor cells without damaging healthy cells. Also, 3D organoids have displayed incomparable advantages over the previous modeling approaches.

• Firstly, it’s feasible and convenient to perform CRISPR-based gene engineering on these models by introducing any combination of cancer gene alterations.
• Secondly, there are many kinds of cells in the organoid system, which retain the in vivo microenvironment to some extent.
• Thirdly, they simulated the original organs in the architecture and function aspects, which is also a predominant feature of such models.
• Finally, they can preserve genetic stability, and the model establishment cycle is highly efficient.

Applications of 3D Normal Organoid Models

Since its birth, the 3D normal organoid model has been seen as a powerful supplement to existing preclinical models. Generated from healthy donor tissues, they are suitable for drug toxicity assessment including hepatotoxicity, cardiotoxicity and nephrotoxicity testing. In addition, they can be applied in cancer modeling and provide new insights into the study of tumor progression and screening personalized drugs for precision medicine. More importantly, they are promising for regenerative medicine. For instance, healthy organoids generated by modern genome-editing technology in an in vitro setting can be subsequently transferred to patients for organ transplantation.

Fig.2 Potential applications of 3D normal organoids. (Creative Biolabs)

Hot Normal Organoid Models

Until now, Creative Biolabs has successfully built a 3D organoid model network mainly involving the following types. These high-quality products are derived from various organs and are easy to access for our existing or potential customers worldwide. With many years of customer service experience in the field of biology, we have gained the extensive trust of our customers and have enough confidence in our capabilities in 3D biology and organoid research.

Related Services

In addition to rich 3D ex vivo models, Creative Biolabs also provides professional technical services in response to pluralistic research requirements. We will constantly enhance our professionalism and are always ready to help your project achieve great success. Please don't hesitate to contact us to learn more about our highly customizable models and a tailored quote.

Related Sections:

• 3D Tumor Organoid Model
• Bespoke 3D Organoid Model