3D Biology Based Neurological Disorder Drug Discovery and Development

Neurological disorders are a global public health problem with a huge market demand. To accelerate the development process of neurological disorder drugs, Creative Biolabs provides 3D biology-based neurological disorder drug discovery and development services for global researchers.

The Importance of Neurological Disorder Drug Development

• Neurological disorders are diseases that affect the central nervous system and peripheral nervous system, such as Alzheimer's disease, Parkinson's disease, stroke, depression, anxiety, autism, etc. These diseases often cause symptoms such as memory and cognitive decline, muscle motor dysfunction, and emotional instability, which place a huge burden on patients and their families.
• There is currently no drug that can cure or completely control these diseases. Existing drugs can only alleviate symptoms, but cannot restore dead or damaged neurons and damaged neural networks. In addition, the existing drugs also have many side effects, such as drowsiness, dizziness, etc., which affect the life quality of patients.

Therefore, the development of more effective drugs for neurological disorders is particularly urgent. Scientists have discovered multiple therapeutic targets related to the development of neurological disorders, such as Tau, β-amyloid, and acetylcholine receptors, and drug candidates targeting these targets are being developed or have already entered the clinic experimental stage.

Why Choose 3D Model for Neurological Disorder Drug Development?

In order to more accurately evaluate the efficacy and toxicity of drug candidates for neurological disorders, it is crucial to select models that can better simulate the human body's tissue structure, physiological function, and drug metabolism process. With the continuous progress and innovation of biotechnology, 3D models have been realized and used more and more widely in the development of neurological disorder drugs.

Fig.1 Human stem cells can be used to generate mini-brain and spinal cord models.¹

Compared with traditional cell models and animal models, 3D models have the following advantages.

Simulate the pathological process of neurological disorders closer to the human body

By using cells to construct 3D models, the microenvironment of nerve cells and the pathological process of diseases can be better simulated. This allows the drug's effectiveness and side effects to be tested under more realistic conditions. The obtained research results are more reliable and predictive.

Lower usage cost and faster feedback time

Compared with animal models, the cost of 3D model construction and cultivation is lower and the experiment cycle is shorter, avoiding lengthy and expensive experiments on animals. In addition, using 3D models can enable high-throughput screening of neurological disorder drugs.

Predicting drug-receptor interactions

The interaction between neurological disorder drugs and receptors can be predicted by using 3D models, thereby predicting the activity and selectivity of drugs. This approach could allow researchers to more quickly screen-specific drug candidates for neurological disorders.

3D Model Constructing Service for Neurological Disorder Drug Development

Creative Biolabs has a professional team of scientists, an advanced technology platform, and rich experience. According to the needs and actual conditions of customers, we will provide 3D spheroid model construction and functional research services for neurological disorder drug development.

• Customize different types of 3D spheroid models
• Cell proliferation and cell death assays
• Receptor expression and functional analysis
• Cytotoxicity test
• Pharmacodynamic analysis
• Other feasible analysis

If you want to improve the efficiency and reliability of drug development for neurological disorders, please contact us.

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