3D Ex Vivo Human Neurological System Tissue Model Introduction

As a reputable biological company, our ex vivo human neurological system tissue models are highly customizable and can be easily tailored to meet your needs. At Creative Biolabs, our reliable 3D ex vivo human neurological system tissue models can assist your preclinical drug discovery projects.

Overview of Neurological Disorders (NDs)

The nervous system is a complex system that plays a vital role in regulating and coordinating body movements. NDs are defined as disorders that affect the brain and the nerves throughout the body and spinal cord. Typical symptoms of NDs include paralysis, muscle weakness, loss of sensation, pain and altered levels of consciousness. NDs are closely linked to a variety of factors, such as genetics, congenital abnormalities, infections, malnutrition and brain damage. Currently, a variety of in vivo and in vitro models are widely used in NDs research.

Limitations of Traditional Models

Common cell culture models and animal models are crucial tools for NDs research, but these models have some shortcomings. Typical shortcomings of in vitro cell culture models include their simplicity and their inability to generate scalable and reliable results to predict in vivo responses. In addition, the widely used in vivo model systems also have some disadvantages. Healing mechanisms, for example, are highly influenced by the cause, extent and size of the injury, which is not easily replicated and quantified in animal models. A typical limitation of animals as preclinical models is the biological mismatch. Due to the immunological and pathological differences, animal models cannot truly mimic human neural injury.

Advantages of Ex Vivo Human Neurological Tissue Models

For structural and functional reasons, reliable models mimicking the human condition are urgently needed to study the mechanisms and develop clinically effective and safe therapeutic strategies for neurological pathologies. Currently, more and more ex vivo models have been developed to complement the lack of studies based on in vitro and in vivo animal models. These ex vivo models have various advantages.

Fig.1 Tridimensional human brain-derived models comparative. (Nogueira, 2022)

Compared with conventional cell culture, the ex vivo tissue partly maintained the original tissue structure with some intact functional neural networks. Therefore, these models are the closest approximation to the in vivo conditions.
Ex vivo tissue models are relatively easy to establish and can be used for short-term and long-term experiments.
These models can mimic lesion pathology and thus play a crucial role in the study of pathological and regenerative pathways in tissue-like complexity.
These models allow controlled evaluation of specific parameters such as cell behavior and tissue regeneration. Improvements in ex vivo models can reduce the number of parameters that must be tested in animal models, thereby reducing the number of animals required.
Ex vivo models of the human nervous system would allow preclinical testing of promising repair strategies, including gene and neuronal cell therapy approaches under human conditions.

Ex vivo Models for Neural Tissue

Here, Creative Biolabs has developed and evaluated a variety of human neurological system tissue models ex vivo, providing a powerful platform for our global customers to study the pathophysiological mechanism of NDs and develop promising therapeutic strategies.

Please contact us in time to learn more about our highly customizable organization models and a detailed quote.

Reference

Nogueira, G.O.; et al. Modeling the human brain with ex vivo slices and in vitro organoids for translational neuroscience. Frontiers in Neuroscience. 2022, 16.

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