3D Hepatocyte-Stellate Cell Spheroid Model

Introduction

Creative Biolabs is delighted to introduce our revolutionary 3D hepatocyte-stellate cell spheroid model as an indispensable tool for your scientific investigations. This meticulously crafted model faithfully reproduces the intricate cell crosstalk of human tissue, enabling your liver toxicity research with remarkable fidelity.

Cytospheroid histology. (Zhou, et al., 2016)

Limitations of Conventional Models for Liver Toxicity Research

Numerous studies have demonstrated that cell-to-cell interactions among hepatocytes, and between hepatocytes and other supportive cells such as hepatic stellate cells, are crucial for maintaining the vitality and functionality of liver tissue in vitro, particularly in terms of drug toxicity and overall hepatic responses. However, conventional 2D culture models completely overlook the cell-cell interactions that occur within a 3D environment. On the other hand, it has been reported that hepatotoxicity had an extremely poor animal-to-human correlation due to the intrinsic interspecies differences with regard to both liver physiology and metabolic capacity of animals.

Hepatocyte-stellate cell spheroid aggregation. (Green, et al., 2010)

Why Choose 3D Hepatic Stellate-Endothelial Cell Spheroid Model

3D in vitro cell-based methodologies are increasingly recognized as a crucially significant emerging technology for advancing pre-clinical research in liver toxicity. The human 3D hepatocyte-stellate cell spheroid model developed by Creative Biolabs is an innovative liver toxicity model that entails the co-culturing of cells in a predetermined ratio. Hepatic stellate cells and hepatocyte effectively reproduces and form the intricate microenvironment of liver, furthermore, they substantially enhance liver-specific functions.

Key Features

Creative Biolabs presents a promising approach for clinical translation and alternative organ replacement therapies, effectively bridging the gap between mouse models and 2D cell cultures to humans by accurately reflecting human liver characteristics, prolonging cellular functionality and establishing intricate cell-cell crosstalk.

3D Hepatocyte-Stellate Cell Spheroid Model

You may directly obtain the hepatocyte-stellate cell spheroids generated by us using a fixed cell ratio to proceed with your research. Alternatively, you have the option to customize the cell types, quantities, and culture conditions according to your specific needs. We are dedicated to providing you with reliable and reproducible research data, thus contributing to the robustness and credibility of your scientific endeavors. In addition to 3D Hepatocyte-Stellate Cell Spheroid Models, you may also be interested in:

Related Services

Based on the advanced technology platform and seasoned scientific team, Creative Biolabs offers the forefront of spheroid models, alongside expert and tailor-made assay services to our global clients. We extend a warm invitation for you to reach out to us, as we believe that our collaboration would lead to groundbreaking discoveries and significant advancements.

References

Zhou, V.X.; et al. Direct orthotopic implantation of hepatic organoids. Journal of Surgical Research. 2017, 211: 251-260.
Green, J.; et al. Non-local models for the formation of hepatocyte-stellate cell aggregates. Journal of Theoretical Biology. 2010, 267(1): 106-120.

Research Model

3D Biology Based Biomarker Discovery

3D Biology Based Drug Discovery and Development

3D Biology Based Toxicity Evaluation

Supporting Assays

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Research Model

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