3D Biology Based Phototoxicity & Photoallergy Evaluation Services

By harnessing the power of 3D cell models, we provide an in-depth and comprehensive understanding of substance toxicity. At Creative Biolabs, we redefine the standards in evaluating phototoxicity and photoallergy, bringing a new dimension to toxicity assessments for enhanced precision and reliability in drug development and safety testing.

Phototoxicity & Photoallergy

Phototoxicity and photoallergy occur when certain chemicals come into contact with the skin and are exposed to light or UV radiation, resulting in acute toxic reactions or an acquired immune reaction.

Mechanisms of phototoxicity. (Tokura, 2018)

Phototoxicity Evaluation by Human 3D Dermal Model

Utilizing human epidermal models that retain its intricate 3D tissue structure, Creative Biolabs has successfully devised an MTT viability phototoxicity assay program anchored upon the chlorpromazine-positive control. This pioneering platform for compound evaluation diligently maintains the physiological conditions of the pristine tissue, endowing your research endeavors with unparalleled precision and predictive capabilities.

Traditional Research or Creative Biolabs 3D Toxicity Evaluation?

Significant variations exist in the activity and catalytic efficiency of various metabolic enzymes between animals and humans. Consequently, there is a lack of consistency between human and animal responses to toxicity and allergic reactions.

At Creative Biolabs, we provide a comprehensive 3D biology-based phototoxicity and photoallergy evaluation service, meticulously tailored to meet the unique requirements of our esteemed clientele. Our evaluation program encompasses the following:

Absorption Spectrum Measurement of Compounds
3D Biology-Based Neutral Red Uptake Phototoxicity Assay
3D Biology-Based MTT Cytotoxicity Testing
3D Biology-Based Photoreactive Peptide Depletion Assay
Luciferase Keratinocyte Activation Assay

Driving Toxicology Advancements

Creative Biolabs is armed with extensive knowledge of the intricacies of toxicology, diligently guides you through the entire evaluation process, from experimental design to data analysis. By leveraging our expertise and state-of-the-art facilities, we deliver meticulous assessments of compound-induced toxicity and equip you with the information needed to make informed decisions in your endeavors.

Reach out to Creative Biolabs

Discover how our 3D biology-based toxicity evaluation can empower your research and development process. Our team of experts is here to provide comprehensive support and tailor-made solutions to meet your specific needs. Contact us now to embark on a journey of excellence together.

References

Tokura, Y.; et al. Drug photoallergy. Journal of Cutaneous Immunology and Allergy. 2018, 10: 12017.
Gaspar, L.R.; et al. Skin phototoxicity of cosmetic formulations containing photounstable and photostable UV-filters and vitamin A palmitate. Toxicology in Vitro. 2012, 10: 887.

Research Model

3D Biology Based Biomarker Discovery

3D Biology Based Drug Discovery and Development

3D Biology Based Toxicity Evaluation

Supporting Assays