3D Biology Based Biomarker Discovery Services

Spheroids, three-dimensional (3D) cell aggregates that can resemble tissues and microtumors, are the key that unlocks the door to 3D Biology study. Creative Biolabs has established a world-class team with pertinent experience in cell biology research and started actively researching 3D biology since then. We gradually create specific frameworks and reliable methods based on our years of experience in cell biology research experience. For our clients around the globe, we offer thorough and specialized services in the area of 3D biology.

Characteristics of 3D Biology

To find cell biomarkers throughout the past few decades, conventional cell culture procedures including two-dimensional (2D) cell culture and removing disease cells from their natural milieu have been the primary approaches. The most significant shortcoming of these approaches is their inability to discover clinically meaningful indicators and adequately depict the microenvironment. Besides, other main differences between 2D and 3D cell cultures have been illustrated in Figure 1.

• The cell-cell interactions are increased.
• It creates an oxygen and nutrient gradient.
• It can recapitulate the tumor microenvironment in vitro.
• Cells of the aggregates are differently exposed to the drug molecules.

Fig.1 The main differences between 3D and 2D cell culture methods. (Fontana, 2020)

Why Choose 3D Biology?

In recent years, 3D cell culture methods have shown great promise for producing realistic tissue and disease models. Several studies have compared the various growth techniques and found that cancer cells grown in 3D models are more phenotypically stable and closer to the phenotype of the parent cell line than 2D-cultured cancer cells. Moreover, based on drug discovery-associated trials, drug resistance in cancer cells produced in 3D models is comparable with in vivo resistance. All these findings support the notion that 3D culture platforms can be utilized to identify more clinically relevant and disease characteristics-associated biomarkers.

What Can We Do?

With advanced equipment and platforms, Creative Biolabs can provide our clients with 3D biology-based biomarker discovery services.

Creative Biolabs has built a knowledgeable team of skilled specialists for each item and set clear methodology in this field. Don't hesitate to contact us for additional information about your 3D biology-associated project.

Related Sections:

• 3D Biology Based Drug Discovery and Development Services
• 3D Biology Based Toxicity Evaluation Services
• Supporting Assay Services