Creative Biolabs has a tradition of commitment. To achieve efficient execution and regulatory approval, we offer careful considerations of your program for the development of a cellular or gene therapy product – now and in the future.
EXPLORE MORE HighlightsWe focus on unmet needs and develop novel cellular and gene drugs and solutions that offer significant benefits over existing options.
EXPLORE MORE HighlightsThe advent of Chimeric Antigen Receptor T-cell (CAR-T) therapies has revolutionized the field of oncology, providing new avenues for treating various forms of cancer. Our 20 years of experience in the biotechnology sector have equipped us with the expertise and technological capabilities to support the entire lifecycle of CAR-T products, from early development to commercialization.
EXPLORE MORETo accelerate advanced breakthroughs of your projects, we offer broad range of platforms which enable our clients be free to tackle problems with cutting-edge technologies from different angles and in different methods.
EXPLORE MORE HighlightsUse the resources in our library to help you understand your options and make critical decisions for your study. We offer oncolytic virus, CAR-T, and dendritic cell related documents, as well as newsletter. If you don't find the answers you're looking for, contact us for additional assistance.
EXPLORE MORE HighlightsGet a real taste and understanding of the business and culture of one of the world's great research-based cellular and gene therapy discovery and development companies.
EXPLORE MOREAll products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.
Human γδ T cells play unique and critical roles in stress monitoring, immunity to infection, and carcinogenesis. γδ T cells have a unique advantage used in cell therapy as they can be independent of human leukocyte antigen (HLA) restriction to identify and kill transformed cells. CAR-γδ T cells that express CAR molecules that target surface antigens on tumor cells to mediate a series of tumor elimination, which will be a huge innovation in tumor therapy.
Fig.1 Activation and development of γδ T cells in the periphery.1
Characterization of γδ T cells
γδ T cells are promising host cells for CAR constructs with many features:
CAR-γδ T cells for Cancer Immunotherapy
CAR-γδ T cells usually present two-fold antitumor activity after transfection which is mainly by two facets, such as not only via the endogenous γδ TCRs, but also via the CAR specificity. In general, CAR-transduced Vδ2T cells have an increased cytotoxicity efficacy target to relevant tumor cells. Activated Vδ2T cells can also act as APCs and cross-present tumor-derived antigen peptides to CD8 αβ T cells while killing tumor cells. More importantly, CAR-transduced Vδ2T cells retained the ability to cross-present tumor antigens to αβ T cells.
CAR-γδ T Cells at Creative Biolabs
With professional expertise and experience in immunotherapy discovery and development, Creative Biolabs has developed a novel CellRapeutics™ platform to support our global customers' cellular therapy research, offering comprehensive antigen-targeting CAR-γδ T cells products to accelerate and advance your programs. At the same time, we are dedicated to customizing special CAR products according to the customer's special needs. Please feel free to contact us or inquire about an appropriate product or solution for you.
Reference
Associated Antigen Target
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NEW SOLUTION
CellRapeutics™ In Vivo Cell Engineering: One-stop in vivo T/B/NK cell and macrophage engineering services covering vectors construction to function verification.
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NOVEL TECHNOLOGY
Silence™ CAR-T Cell: A novel platform to enhance CAR-T cell immunotherapy by combining RNAi technology to suppress genes that may impede CAR functionality.
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Canine CAR-T Therapy Development: From early target discovery, CAR design and construction, cell culture, and transfection, to in vitro and in vivo function validation.
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