3D Ex Vivo Human Eye Tissue Model Introduction

Creative Biolabs has built a comprehensive and extensive procurement network to provide scientific researchers around the world with unparalleled human eyeball tissue models, creating unprecedented research opportunities and possibilities, and promoting your preclinical drug development and disease research.

Fig 1. Corneoscleral rims from a human donor. (Chu, 2014)

Eye and Related Diseases

The eye is a highly complex biological structure, which is the most important part responsible for visual perception, and has the functions of refraction imaging and photosensitive transduction. The eyeball contains many highly heterogeneous structural tissues. Anatomically, the eye can be divided into two asymmetrical parts, the anterior segment and the posterior segment. The anterior segment mainly contains structures such as the cornea, ciliary body, iris, and lens, while the posterior segment consists of the choroid, retina, and vitreous. The structure of the eye plays an important role in maintaining eyeball function and providing effective vision. Eye diseases, including inflammation and glaucoma, are very common and affect the lives of patients to a large extent. The pathophysiological mechanisms of these diseases are not yet fully understood, so it is extremely important to create complex and accurate eye models.

Fig 2. Complex Structure of the anterior segment of the eye. (Posadas, 2020)

Limitations of Common Research Models

The most commonly used ophthalmic research model is the traditional 2D cell culture model, which can be effectively used for drug testing and molecular biology detection, but the ability to reconstruct the complexity of different cell types and functional structures is limited. Rodent eyes are fundamentally different from human eyes, and research using non-human primates is extremely labor-intensive and inefficient. In fact, each tissue that makes up the eye has unique characteristics, and for some complex structures of the eye, there are no proper and valid research models.

Fig 3. SEM of eye. (Posadas, 2020)

Why Choose 3D Ex Vivo Human Eye Tissue Model?

The human-isolated eyeball tissue model has perfect structural reproducibility, and our excellent extraction, preservation and delivery links ensure the quality of the tissue model. These tissues with higher RNA integrity index scores will provide a new perspective for ophthalmic disease-related research. Through the close cooperation of hospitals, transplant centers and organ donation organizations.

Creative Biolabs has created a human tissue supply network all over the world including:

Our comprehensive and standardized tissue collection procedures allow us to provide you with high-quality human tissues that are superior to peers, thereby greatly optimizing the research efficiency of your drug development and avoiding costly late-stage failures. You are allowed to freely set the standards for the tissues and cells, and we will provide you with tissue samples and related human data that have undergone professional medical testing and ethical evaluation. Good experimental results are inseparable from the support of excellent experimental models, and the human-isolated tissue models we provide will be irreplaceable tools for your drug development and pathological research, so please don't hesitate to contact us for more information.

References

Chu, E.; et al. Tissue-based imaging model of human trabecular meshwork. Journal of Ocular Pharmacology and Therapeutics. 2014, 30: 190.
Posadas, L.; et al. Three-dimensional human cell culture models to study the pathophysiology of the anterior eye. Pharmaceutics. 2020, 12: 1215.

Research Model

3D Biology Based Biomarker Discovery

3D Biology Based Drug Discovery and Development

3D Biology Based Toxicity Evaluation

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