3D Ex Vivo Human Lung Tissue Model Introduction

After years of accumulation and development, Creative Biolabs has become a reputable supplier in the field of human ex vivo models. At Creative Biolabs, a variety of custom ex vivo models of lung infection are available. We are your loyal partner in lung disease research.

Overview of Lung Diseases

The lung is an important organ that plays a vital role in human life activities. There are many types of lung diseases, such as asthma, influenza, pneumonia, tuberculosis and lung cancer. In addition, some lung diseases can cause respiratory failure. Lung disease is closely linked to a variety of factors, including smoking, infections and genes. For a long time, lung diseases have received widespread attention. Ex vivo models of human lung tissue are now valuable for studying pneumonia-related host-pathogen interactions.

Fig.1 Respiratory diseases. (Bisserier, 2022)

Drawbacks of Traditional Models

Most research on lung infection in humans relies on animal and cell models. However, the results obtained from these studies are poorly representative of the complex molecular events that occur in intact human lung tissue in vivo.

Fig.2 Inadequacies of the traditional model. (Creative Biolabs)

Advantages of Ex vivo Human Lung Tissue Models

• Ex vivo lung tissue models are emerging as attractive tools for studying lung infection because these models can overcome some of the limitations of and complement traditional models.
• The ex vivo 3D lung model allows for a better simulation of the in vivo environment, as it preserves the vascular space with the natural architecture of the perfusable organ.
• Ex vivo human lung models provide a useful additional experimental preparation for animal models.
• The ex vivo model allows the study of the interaction of different cell types in intact human lung tissue.
• This model provides information on the complex communication between different histiocytes and the extracellular matrix in intact tissues.
• The model overcomes some differences between human and animal species.
• Ex vivo infected human lung tissue plays an indispensable role in studying the fundamentals of pathogen-host interactions in the lung.

Applications of Ex vivo Human Lung Tissue Models in Lung Infection

With a global large-scale tissue procurement network and rich market experience, Creative Biolabs is committed to providing first-class human lung tissue ex vivo tissue models to escort your preclinical drug development. The models we can provide are listed below. For more details, please feel free to contact us.

• 3D Ex Vivo Precision-cut Lung Slices (PCLS) Model
• 3D Ex Vivo Pulmonary Artery Bath Model
• 3D Ex Vivo Airway Contractility Model

Related Sections:

• Ex Vivo Human Genitourinary Tissue Model
• Ex Vivo Human Skin System Tissue Model
• Ex Vivo Human Urinary System Tissue Model
• Ex Vivo Neurological System Model
• Ex Vivo Human Digestive System Model
• Ex Vivo Human Musculoskeletal System Tissue Model
• Ex Vivo Human Respiratory System Tissue Model
• Ex Vivo Human Endocrine System Tissue Model
• Ex Vivo Human Cardiovascular Tissue Model