3D Ex Vivo Human Naturally Occuring Skin Disease Model Introduction

Creative Biolabs provides high-quality human naturally occurring skin disease model collected from human donations for research purposes. We understand the importance of accurate and reliable models in the field of skin disease research, and our goal is to provide researchers with the best tools to advance their projects.

Skin System and Skin Disease

Skin system tissue, the largest organ in the human body, is a complex system of multiple layers that performs various functions. Skin diseases are common and can significantly impact a person's quality of life. These diseases can range from mild to severe and can affect people of all ages. Research on skin diseases aims to understand the underlying mechanisms that lead to these conditions and develop new treatments. Various skin diseases, such as psoriasis, eczema, and vitiligo, have been studied using animal models, which have limitations in accurately representing human disease.

Fig 1. Schematic of human skin tissue.¹

Traditional Models for Skin Disease Research

Traditionally, animal models such as mice and rat models have been used for skin disease research. However, animal models have limitations due to differences in the skin anatomy and physiology between humans and animals, which may affect the validity of the research results. Additionally, ethical concerns and high costs associated with the use of animal models have led researchers to seek alternative models for skin disease research.

3D Ex Vivo Human Naturally Occurring Skin Disease Model

Our 3D ex vivo human model of naturally occurring skin diseases provides the most clinically relevant opportunity for in vitro evaluation of any skin disease-related tests and experiments. Large-molecule proteins such as monoclonal antibodies, biosimilars, and biologics that elicit adverse immune reactions can be tested ex vivo using fresh and complete functional human skin. Furthermore, our model can be utilized to identify toxicological endpoints such as dose-response relationships, cell viability, apoptosis, necrosis, as well as the effects of compounds or drugs on cytokines, chemokines, and growth factors, or the cost-effective commercialization of products or drugs in the cosmetics, chemical, and pharmaceutical industries.

Looking for More Models?

3D ex vivo human naturally occurring skin disease model provides the most human-relevant assessment tool for any of your relevant research. You may also choose our higher-throughput model, which utilizes fresh human skin with induced disease-related inflammatory phenotypes, or a 3D full-layer skin model of melanoma with a fully developed stratum corneum.

Main Features

Our valuable model offers several key benefits, which including but not limited to:

• Reflecting disease biology using diseased tissue from the target patient population
• Providing biopsies from patients with psoriasis or atopic dermatitis
• Supplying donor information that can be used to supplement pharmacological data
• Offering disease severity scoring

Our Services

Our outstanding 3D human naturally occurring skin disease model offers unparalleled physiological and morphological relevance to the original species. Particularly, we provide naturally occurring psoriasis and atopic dermatitis models for your research. With years of experience, Creative Biolabs is dedicated to advancing scientific research by providing exceptional service. For more detailed information, please feel free to contact us.

Related Sections:

• Ex Vivo Human Genitourinary Tissue Model
• Ex Vivo Human Skin System Tissue Model
• Ex Vivo Human Urinary System Tissue Model
• Ex Vivo Neurological System Model
• Ex Vivo Human Digestive System Model
• Ex Vivo Human Musculoskeletal System Tissue Model
• Ex Vivo Human Respiratory System Tissue Model
• Ex Vivo Human Endocrine System Tissue Model
• Ex Vivo Human Cardiovascular Tissue Model