3D Ex Vivo Neuroinflammation Model Introduction

With advanced proprietary technology and abundant resources, Creative Biolabs provides our clients with human-derived 3D neuroinflammation models with the highest safety and efficacy. Continuing attention to the human target and the source of the body maintains the human activity of the tissue model to the greatest extent, reduces misleading information caused by species differences, and provides a perfect tool for your pathological research and drug development.

Fig 1. Activation of microglial inflammation. (Park, 2018)

Neuroinflammation and Related Diseases

Neuroinflammation is defined as the activation of the innate immune system in response to inflammatory challenges, characterized by a multitude of cellular and molecular responses in the brain. During this process, inflammatory mediators produced by CNS cells induce the production of chemokines, stimulate glial cells and recruit immune cells. This process involves multiple neuroinflammatory markers, including tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-1β (IL-10), nitric oxide (NO), etc. These markers and related cellular activities will lead to many neurodegenerative or neuronal diseases. A more accurate human brain model and further mechanism research and drug testing will be an urgent need for the development of prevention or intervention methods for such diseases.

Limitations of Traditional Research Models

Pathological studies of neurodegenerative diseases and neuroinflammation are usually carried out through cell models or animal models. Although two-dimensional cell culture models using neurons or microglia can mimic neuronal damage or other molecular processes in pathological processes, they ignore cell interactions at the overall level, so they can only be partial and incomplete evaluation results. The mouse model induced by lipopolysaccharide is a commonly used animal model of neurodegeneration. However, due to differences in the immune system and molecular biology of rodents and humans, therapeutic compounds that are effective in mice often cannot be successfully translated into the expected results in the clinic. In fact, more than 90% of experimental drugs fail in clinical testing.

Why Choose 3D Ex Vivo Neuroinflammation Model

Backed by our unique and optimized technology and partnerships with many neurological disease research institutions, Creative Biolabs has the ability to fill the gap in 3D neuroinflammation models. We provide you with disease modeling of human cells, phenotypic screening services, as well as high-quality healthy or diseased human tissue samples recovered by proprietary methods. We have many years of experience in purchasing and processing qualified human tissue samples. These precious samples will be well preserved and delivered to your hands with maximum proteomics and metabolomics reduction.

More Ex Vivo Models at Creative Biolabs

Creative Biolabs has developed an extensive tissue procurement network, therefore, a wide variety of ex vivo tissue models are available.

These precious, well-characterized and certified 3D tissue models will overcome the dimensional limitations or species differences of classical models, providing unprecedented support for your drug development and pathology research, so please don't hesitate to contact us and discuss your needs.

References

Park, J.; et al. A 3D human triculture system modeling neurodegeneration and neuroinflammation in Alzheimer's disease. Nature Neuroscience. 2018, 21: 941-951.
Tufekci, K.U.; et al. The endotoxin-induced neuroinflammation model of Parkinson's disease. Biomicrofluidics. 2020, 14: 061507.

Research Model

3D Biology Based Biomarker Discovery

3D Biology Based Drug Discovery and Development

3D Biology Based Toxicity Evaluation

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