3D Ex Vivo Human Spinal Cord Tissue Model Introduction

The spinal cord is a tubular structure that makes up an important part of the central nervous system. Spinal cord diseases (SCDs) can originate outside or inside the spinal cord. To develop clinically effective and safe therapeutics, human ex vivo tissue models are needed to complement studies based on in vitro and in vivo animal models. Creative Biolabs is a biological company focused on providing 3D ex vivo human tissue models. With our integrated global resources, our ex vivo human spinal cord tissue models will provide you with a cutting-edge platform to support your preclinical drug development.

Fig.1 Schematic of the human spinal cord and peripheral nerve anatomy. (Xue, 2021)

Importance of Ex Vivo Models

Currently, most attempts at applying cells to model SCD rely on two-dimensional (2D) cell cultures. But the 2D cell model does not include the complex physiological environment of the spinal cord. Therefore, these models do not accurately represent the conditions in the spinal cord. Furthermore, in vitro models also have the disadvantage of not being biologically active. Of note, in vivo spinal cord injury models have been used to study SCD. However, due to the complex in vivo environment, it is difficult to interpret the experimental results. Importantly, animal studies alone are insufficient to understand human spinal cord pathology. Based on the above reasons, the human tissue ex vivo model is considered a promising model to study SCD to overcome the shortcomings of in vivo and in vitro models.

Advantages of Ex Vivo Models

It is well known that the translation from experimental animal models to the clinic is complex and challenging. To improve the therapeutic effect, it is necessary to select ex vivo models that mimic human SCD. These models play a crucial role in elucidating the mechanisms involved in injury progression and neuroprotection. There are some prominent advantages over ex vivo models.

Fig.2 Model features. (Creative Biolabs)

Applications

At Creative Biolabs, our human spinal cord tissue samples play a pivotal role in proteomic and transcriptomic studies of the spinal cord. We recovered human spinal cord tissue and cells in a hyperactive state to monitor the effects of compounds on spinal neurons. Our advanced technology allows for maintaining the viability of tissues and cells to ensure experimental results. In addition, our customized spinal cord ex vivo tissue model will help you better understand the pathology of SCD and provide a powerful platform for SCD preclinical drug development. Please do not hesitate to contact us to discuss your project.

More 3D ex vivo human neurological system tissue models are available by visiting the link below:

Fig.2 Ex vivo neurological system tissue models. (Creative Biolabs)