3D Ex Vivo Human Vertebral Column Tissue Model Introduction

Procurement partnerships with multiple research institutions and specialty clinics have resulted in our mature and comprehensive human tissue specimen library, allowing Creative Biolabs to provide standardized or custom collection protocols for human vertebral columns to scientific researchers around the world.

Vertebral Column and Related Diseases

The vertebral column is located in the middle of the back, the upper part connects to the skull, and the lower part reaches the tailbone. Anatomically speaking, the adult vertebral column includes 26 vertebrae, forming a longitudinal spinal canal from top to bottom, with a large amount of connective tissue, muscle and soft tissue attached therebetween. Spondylitis and intervertebral discitis are rare diseases that mainly affect adults. With the popularization of invasive surgery, the incidence of such diseases has gradually increased, but there is a lack of effective targeting methods. On the contrary, lumbar pain is very common, and intervertebral disc disease and changes in the shape of the spine are considered to be one of the main causes of lumbar pain. Sedentary is empirically believed to be the culprit of such lesions, but the further pathogenic mechanism is still blank.

Fig 1. Human vertebral column. (Gawel, 2018)

Limitations of Traditional Models

Magnetic resonance imaging (MRI) is the gold standard for visualization of vertebral column disease, providing reliable images of the vertebral column with high-quality soft tissue visualization. MRI is suitable for almost all vertebral column disorders, but noninvasive observations provide only limited data support. Additive manufacturing provides new possibilities for constructing scaffold models with biophysical properties, but a reasonable model requires the assistance of complex scanning data and computational models. Animal models are also commonly used vertebral column research tools, but small animals are usually unable to perform effective vertebral column drug delivery, large animals face higher costs and ethical issues, and most of the compounds that are feasible in animal experiments fail in the stage of clinical translation.

Fig 2. Animal models for vertebral column disease research. (Joyce, 2020)

Why Choos 3D Ex Vivo Human Vertebral Column Tissue?

Creative Biolabs has developed an extensive tissue procurement network, therefore, a wide variety of ex vivo tissue models are available.

• 3D Ex Vivo Human Neurological System Tissue Model
• 3D Ex Vivo Human Digestive System Tissue Model
• 3D Ex Vivo Human Musculoskeletal System Tissue Model
• 3D Ex Vivo Human Reppiratory System Tissue Model
• 3D Ex Vivo Human Endocrine System Tissue Model
• 3D Ex Vivo Human Cardiovascular Tissue Model
• 3D Ex Vivo Human Skin System Tissue Model
• 3D Ex Vivo Human Urinary System Tissue Model
• 3D Ex Vivo Human Genitourinary Tissue Model

We can also process samples under your entrustment, optimize models, and enhance the applicability of these solutions with customizable services. With available and professionally certified pathological confirmation, we ensure that the tissue samples you obtain have the correct donor history, tissue quality and other vital parameters. Our services will provide unparalleled opportunities for your research, so please do not hesitate to contact us and think your plans have been greatly advanced.

Related Sections:

• Ex Vivo Human Genitourinary Tissue Model
• Ex Vivo Human Skin System Tissue Model
• Ex Vivo Human Urinary System Tissue Model
• Ex Vivo Neurological System Model
• Ex Vivo Human Digestive System Model
• Ex Vivo Human Musculoskeletal System Tissue Model
• Ex Vivo Human Respiratory System Tissue Model
• Ex Vivo Human Endocrine System Tissue Model
• Ex Vivo Human Cardiovascular Tissue Model