iPSC-Derived Organoid Model Development

Pluripotent stem cells (PSCs) possess the magical potential of growing indefinitely and differentiating into specific cell types of almost any organ, which offers a sensible solution to create a large amount of disease-related tissues from patients in vitro. Induced PSCs (iPSCs) are obtained by reprogramming somatic cells into the pluripotent stage state. Combined with organoid models, it brings a technological revolution in regenerative medicine. Creative Biolabs is a leading biological company and has explored an efficient path for developing iPSC-derived organoid models. Our iPSC-derived organoids are high-customizable and easily accessible, which will expedite your preclinical drug discovery projects, leading to faster advancements and progress in your research efforts.

Construction of iPSC-derived Organoid Models

Generally speaking, the origin of organoids involves various cell types, such as adult stem cells (ASCs) and several PSCs. The generation process of PSC-derived organoids has been detailedly discussed by researchers as shown in Fig. 1, which offers a good insight into establishing iPSC-derived organoids and can be a referential protocol.

Fig.1 Generation of pluripotent stem-cell-derived organoids. (Hofer, 2021)

Applications of iPSC-derived Organoid Models

In essence, iPSC-derived organoids still belong to 3D culture technologies, so they show many satisfactory advantages of 3D in vitro culture systems. For instance, such models can reduce ethical concerns to a large degree, which usually exist in the use of animal models. Due to the ability to differentiate into patient-specific cells of interest, they are an ideal tool for personalized medicine. Additionally, such models can retain disease phenotypes relevant to genetic mutations. More importantly, iPSCs-derived organoids are very promising for regenerative therapy, drug screening, and disease modeling, which will further accelerate the progress of drug discovery and pave the way for subsequent clinical success.

Fig.2 Applications of pluripotent stem-cell-derived organoids. (Hofer, 2021)

iPSC-derived Organoid Model Development

To date, Creative Biolabs has gathered a flock of excellent scientists to build our professional research team. We have accumulated a lot of successful experience in establishing and maintaining various organoid models. To respond to diversified demands and optimize our service content, Creative Biolabs also designs iPSC-derived organoid development services exclusively for our worldwide customers. We will fully understand your project requirements and generate the most useful and acceptable iPSC-derived organoids based on your claims.

Related Services

To note, in addition to high-quality organoid models, the following 3D biology-based and supporting services are also available for our customers to choose from. If you are interested in any product or service, we will always be delighted to chat with you for further discussion. Please do not hesitate to contact us for more information you desire to obtain.

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• 3D Normal Organoid Model
• Bespoke 3D Organoid Model