Lymphoid Progenitor Assays

Creative Biolabs supports lymphoid progenitor assays by colony-forming unit – Pre-B lymphocyte (CFU-PreB) assays to assist clients in testing lymphotoxicity and quantifying maturation and proliferation of bone marrow progenitor cells into lineage specific lymphoid progenitors.

Colony-Forming Unit – Pre-B Lymphocyte (CFU-PreB)

CFU-pre-B is a progenitor that generates colonies of B-lymphocytes. All cells of the lymphoid lineage are derived from a common lymphoid progenitor, which differentiates from bone marrow hematopoietic stem cells. T cell progenitors derived from common lymphoid progenitors leave the bone marrow through the blood and enter the thymus. These cells continue to grow in the thymus gland, where precursor cells eventually mature into mature T lymphocytes with distinctive surface antigens and useful properties.

Fig.1 Main stages of thymic selection.¹

Importance of Lymphoid Progenitor Assays

Lymphoid progenitor cells must survive and proliferate to generate a typical number of adult lymphocytes. A kind of SCID known as reticular dysgenesis (RD) is distinguished by the presence of significant lymphopenia, agranulocytosis, and sensorineural deafness.

Standard Procedure of CFU-PreB Assays

Applications of Lymphoid Progenitor Assays

• Forecast compound-induced lymphotoxicity brought on by single drugs or a combination of treatments.
• Study cell biology and the development of Pre-B cells.
• Provide data that can be utilized to investigate harmful effects such as cellular immune malfunction.

Creative Biolabs offers a comprehensive suite of tailored megakaryocytic progenitor assay services to streamline every facet of your preclinical drug development research. Please contact us to inform us of your requirements.

Our commitment extends beyond conventional solutions, and with a robust foundation in 3D biology, we aim to provide a transformative dimension to your research endeavors. Creative Biolabs is dedicated to delivering cutting-edge technologies and an extensive repertoire of 3D models. Our models include but transcend the limitations of:

• 3D Spheroid Model
• Organ-on-a-chip Model
• 3D Ex Vivo Human Tissue Model
• Precision-Cut Tissue Slice Model

Related Sections:

• CFC (Colony-Forming Cell) Assays
• High-content Imaging and Analysis
• Tissue Cross-Reactivity Studies
• Gastrointestinal Motility Assays
• Pain-Related Functional Assays