3D Biology Based Metabolome Analysis Service

As a member of systems biology, metabolome aims to comprehend how various elements of biological systems interact and affect an organism's overall performance. Creative Biolabs, with the advanced mass spectrometry analysis platform, can solve your 3D biology research-associated problems. We have rich experience in metabolome analysis and can provide comprehensive and detailed services for our clients worldwide.

What Is Metabolome?

The whole collection of tiny molecules or metabolites from a cell, tissue, or organism is regarded as its metabolome. Any molecule that is less than 1.5 kDa is often considered to be a metabolite. These metabolites are crucial components of cellular functions including energy generation, signaling, and biosynthesis. They are the end products of numerous metabolic pathways that take place inside cells. Metabolome analysis is a systematic examination of the distinctive chemical fingerprints that specific biological activities leave behind.

3D Biology Based Metabolome

Metabolome analysis is widely used in disease diagnosis, pharmaceutical research and development, nutritional food science, toxicology, environmental science, and other fields. For the creation of accurate tissue and disease models that can perfectly mimic the intricate cell-cell interactions and in vivo milieu, 3D biology models hold a lot of potential. By the combination of advancing 3D biology models and in-depth metabolome analysis, more convincing conclusions about drug action mechanisms and target research can be uncovered.

3D biology-based metabolome analysis shows huge potential in natural medicine research and new drug screening. For example, using the metabolic profile, toxicology, and toxicity evaluation may determine the physiological changes brought on by one or a mixture of chemicals-caused harmful insults. For identifying the phenotype brought on by a genetic modification, such as gene insertion or deletion, metabolomics can be a very useful technique.

The Procedure of Metabolome Analysis

• For a typical 3D biology-based metabolomics study process, well-prepared samples are often first taken into consideration.
• Next, metabolites are frequently extracted after some treatments like derivatization or concentration.
• Then, metabolites are separated by gas chromatography (GC), high-performance liquid chromatography (HPLC), or capillary electrophoresis (CE).
• The following identification, analysis, and quantification of metabolites are usually completed by nuclear magnetic resonance (NMR) spectroscopy or mass spectrometry (MS).
• The unprocessed output data might be utilized to extract metabolite features and several bioinformatic methods and programs are available to describe metabolic signatures using current biological information, find the differently changed metabolites, assess significant connections, and uncover links with disease states and outcomes.

Fig.1 The workflow of metabolome analysis. (Creative Biolabs)

Creative Biolabs has been committed to the research of metabolome for a long time. Using the powerful technology platform and years of experience, we keep helping researchers accelerate their metabolome research. To gain a deeper and more comprehensive understanding of the mechanism of the metabolome, please feel free to contact us about your 3D biology-based project.

3D Models Provided by Creative Biolabs

• 3D Spheroid Model
• Organ-on-a-chip Model
• 3D Ex Vivo Human Tissue Model
• 3D Precision-Cut Tissue Slice Model
• 3D Organoid Model

Related Sections:

• 3D Biology Based Multi-Omics Analysis Services
• 3D Biology Based Immune Response Analysis Services
• 3D Biology Based Target Analysis and Validation Services