Myeloid Progenitor Assays

The most frequently and thoroughly studied type of hematological toxicity in vitro is the acute effect of the toxicant on myeloid progenitor cells such as granulocyte-macrophages. Creative Biolabs supports myeloid progenitor assays by Colony-Forming Unit-Granulocyte/Macrophage (CFU-GM) to study the hematotoxicity of drugs and chemicals on the myeloid cell compartment.

The Importance of Myeloid Progenitor Assays

Neutrophils are short-lived, circulating white blood cells that provide a critical line of defense against microbial infections. Neutrophils are continuously produced by rapidly proliferating precursor cells in hematopoietic tissues called colony-forming units-granulocyte/macrophage (CFU-GM), so named because they form clonal colonies in semisolid cell cultures when stimulated with appropriate cytokines. These special cell types produce new replacement neutrophils, and, when they fall to abnormally low levels in the blood, the risk of infection increases.

Standard Procedure of CFU-GM Assays

Applications of Myeloid Progenitor Assays

• Forecast myelotoxicity-induced neutropenia caused by a substance
• Identify single medicines or combination therapy that will cause myelotoxicity.
• Analyze the efficacy of myeloid growth factors
• Study cell biology and myeloid development

Creative Biolabs possesses professional myeloid progenitor assay methods and processes to assist you in your drug development research. With professional model building knowledge and excellent service team, Creative Biolabs promises to provide high quality experimental modes which cover a variety of types at cell, organ, and tissue levels to meet all your research needs. The models we can provide include but are not limited to:

• 3D Spheroid Model
• Organ-on-a-chip Model
• 3D Ex Vivo Human Tissue Model
• Precision-Cut Tissue Slice Model

Please contact us to let us know what you need.

Related Sections:

• CFC (Colony-Forming Cell) Assays
• High-content Imaging and Analysis
• Tissue Cross-Reactivity Studies
• Gastrointestinal Motility Assays
• Pain-Related Functional Assays