Normal Breast Organoid Model

Breast cancer (BC) is a female malignant tumor with a high incidence worldwide. As a result of the limitations of the current models, human understanding of BC development and its regulation by multiple factors is still not deep and comprehensive enough in terms of the molecular and cellular levels. Thus, it is important to establish a reliable model that can represent how these factors influence BC development. Creative Biolabs has made much effort in this regard and is committed to providing high-quality 3D organoids including normal breast organoid models for worldwide customers.

Construction of Normal Breast Organoid Models

Generally speaking, the construction process of breast organoids from normal breast or tumor tissue is semblable. In most cases, the whole protocol is as follows.

Fig.1 Schematic representation of the general process of human breast organoid derivation. (Mohan, 2021)

Advantages of Normal Breast Organoid Models

Recently, applications of 3D organoid cultures have been expanded to breast disease research. Together with patient-derived organoids, normal breast organoids play a role in BC research and have shown many advantages.

• Firstly, normal breast organoids preserve expression patterns of mammary markers and have a similar breast microenvironment to in vivo.
• They offer an accessible platform for further studying the cell-cell and cell-extracellular matrix (ECM) interactions.
• These models are easy to manipulate, so they are suitable for recapitulating oncogenesis by means of gene-editing technology.
• Moreover, such models can be established with high efficiency for a collection of purposes and obtain a long-term expansion ability in vitro.
• In this kind of normal organoid culture, almost all complex epithelial lineages of breast tissue can be better retained, enabling a better understanding of the genesis of different BC subtypes.
• These organoids create an evaluable tool for further research on normal mammary lineages.

Applications of Normal Breast Organoid Models

Studies have found that normal breast organoids possess a multipurpose nature, in particular for studying the development of the mammary gland. Combined with advanced gene editing technology, they can be used in disease modeling. Additionally, such organoids show great potential to conduct drug efficacy assessment and have been frequently utilized to examine factors that are related to signaling transduction, gene expression, and tissue remodeling.

Related Services

Over the years, Creative Biolabs has focused on the development of 3D organoid models and have developed a series of 3D organoid models including normal breast organoids. These reliable and high-quality products have attracted a stable and increasingly expanded group of customers, which give us more confidence and motivation to go far in this 3D biology field. Besides, in order to ensure customers to get a better product experience, we also provide high-customized technical services to our customers. Please feel free to contact us for more details.

Related Sections:

• 3D Tumor Organoid Model
• 3D Normal Organoid Model
• Bespoke 3D Organoid Model