Normal Cardiac Organoid Model

As biology technology develops rapidly, the demand for organoid models in biology is becoming more and more vigorous. The same situation appears in the field of heart disease research. Creative Biolabs is leading in providing 3D ex vivo models including high-quality and customizable normal cardiac organoids to customers. Our scientific team is committed to delivering top-notch service to support your drug discovery project's success.

Construction of Normal Cardiac Organoid Models

The cardiac organoids start from human pluripotent stem cells (hPSCs). As shown in Fig.1, they can be and are subsequently generated by directed differentiation or self-aggregation of hPSCs. Among them, the directed differentiation method relies on anti-adherent plates to culture different cardiac cells. It should be noted that adding shaking operations and biological scaffolds will help the cardiac organoids grow better.

Fig.1 Schema of construction of human cardiac organoids. (Sahara, 2023)

Advantages of Normal Cardiac Organoid Models

Common 2D cell cultures fail to reproduce morphogenetic and physiological processes in vitro, which limits their extensive applications in modeling the early stage of heart tissues and disease. The emerging 3D organoid culture models are an evaluable platform for heart diseases and have been pinned high hope to solve these drawbacks. The specific advantages of such models are as follows.

• Show a high similarity to the real heart in terms of their structures and functions, thus be suitable for the study of cardiogenesis and medicine.
• Contain multiple types of cardiac cells, so be capable of reproducing the original tissue more faithfully.
• Display cell and cell interaction behaviors in vitro, which will never appear in conventional culture models.
• Allow much higher throughput to conduct drug screening because of the simple fabrication process and smaller cell number.
• Contribute to the personalized management of patients by predicting the drug response in vivo and gene expression changes.

Applications of Normal Cardiac Organoid Models

Because of the above advantages, cardiac organoids become increasingly popular and attracted a lot of attention in recent years. To our knowledge, they have been already successfully used in a series of basic research and preclinical research. What’s more, the ongoing research is gradually overcoming the existing technology challenges step-by-step to further facilitate their applications in a wider range.

Fig.2 Schema of applications of human cardiac organoIds. (Sahara, 2023)

Related Services

Based on our professional technical team, Creative Biolabs is devoted to providing 3D ex vivo physiological models for global customers. To date, our organoid products have benefited many customers and received abundant positive reviews, which strengthens our faith in making more breakthroughs in the 3D biology field. In addition to rich organoid products, we also provide a series of technical services listed below. If you have any research needs, please do not hesitate to contact us for rapid success.

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