Normal Colon Organoid Model

After years of effort in colon cancer management, the life expectancy of patients has improved. However, the disease relapses resulting from metastatic progression and drug resistance remain unsolved. Thus, the discovery and development of new therapeutic strategies for advanced tumors are urgently needed. Creative Biolabs is leading in developing organoid models and has gathered rich modeling experience in colon cancer area. Our normal colon organoid models are high-customizable and easily accessible, which will help your preclinical drug discovery projects achieve rapid progress.

Advantages of Normal Colon Organoid Models

In the last decades, ex vivo organoid technology is gradually going strong. As one of the forms, normal organoid models play an increasingly significant role in colon cancer research. Many reports have discussed they are superior to previous models in many aspects. In summary, their unique advantages including the following points need to be emphasized so that such models can be more extensively utilized in the future.

• In most cases, these models are generated from the normal patient sample. They can retain both structure and heterogeneity of the original tissue in the long-term in vitro culture process.
• These organoid models show complex stem cell niches of the colon crypts and display great potential to model environmental exposures.
• They help better understand both tumor biology and normal tissue homeostasis and are easy to genetically manipulate in vitro.
• The establishment and use of organoids avoid ethical issues frequently arising in animal models.

Applications of Normal Colon Organoid Models

With the gradual popularization of organoid technology, normal organoid models have been gradually applied in a wide spectrum of colon-related disease research. It’s no doubt that this 3D organoid culture system has become a novel platform to study the basic biology of gastrointestinal cancers. Besides, they are seen as the preferred brand when there is a need to predict individual treatment responses of patients. It’s obvious that organoid technology will become the mainstay of colorectal cancer research by combing itself with other emerging technologies in the future.

Fig.1 Organoids derived from normal tissue are useful for studying physiology. (Li, 2020)

Related Services

After years of unremitting efforts, Creative Biolabs has attracted a group of excellent researchers to build our powerful research team. We have a robust human tissue procurement system, which supports the quick development of 3D organoid models including normal colon organoids. Aside from high-quality organoid models, we also fine-design a collection of supporting services for our global customers to choose from. As long as you have needs, it would be our pleasure to provide you with pre-sales and after-sales supports. For more details, please feel free to contact us.

Related Sections:

• 3D Tumor Organoid Model
• 3D Normal Organoid Model
• Bespoke 3D Organoid Model