Normal Liver Organoid Model

Creative Biolabs is a biology company specializing in the development of ex vivo organoid models and has accumulated rich experience in the construction of this kind of physiological model. Our normal liver organoid models are highly customized and will help your preclinical drug discovery projects achieve rapid progress.

Construction of Normal Liver Organoid Models

To our knowledge, liver organoids can be generated from a variety of cell types, which proves organoid technology is gradually becoming more mature and accessible. Fig.1 demonstrates the derivation process of liver organoids including normal liver organoids from different cell types, indicating a complementary option in our toolbox to deepen our understanding of the liver organ.

Fig.1 Liver organoids can be derived from various cells. (Prior, 2019)

Advantages of Normal Liver Organoid Models

Since their emerge, organoids have displayed their capability of filling the gap between 2D cultures and in vivo models. They possess some popular advantages over 2D cell culture systems.

• More physiologically relevant than conventional cell culture in vitro models.
• Reflect the signaling pathways existing in the native organ and constitute a novel model of reproducing in vivo biology.
• Simulate the derived organ in the tissue architecture and functions.
• Be suitable for regenerative medicine, owing to their reproducibility, scalability and safety as well as their high cost-effectiveness.
• Be convenient to perform genome editing.
• Mimic in vivo tissue microenvironments, thus they can reflect closer drug responses as observed in clinical research.

Applications of Normal Liver Organoid Models

From recent research, we can discover that normal liver organoids play an indispensable role in basic research and clinical research like other liver organoids. Due to the natural strengths of micro-organs, they are appropriate for investigating the development and function of healthy liver and dissecting the disease mechanisms, further paving the way for therapeutic applications. Based on gene engineering technology, normal liver organoids can be used in disease modeling and drug screening. Moreover, they have shown great potential for a series of applications, such as regenerative medicine, personalized medicine, and drug toxicology studies.

Fig.2 Applications of liver organoids. (Prior, 2019)

Related Services

After continuous development and growth, Creative Biolabs has expand its business into the 3D organoid model field. We always pursue the most advanced technology and constantly strive for the goal of providing our global customers with the most reliable products and the highest quality service. To date, our product network has contained a collection of 3D organoids including normal liver organoids. We strive to offer you the best possible service to assist you in achieving success with your research project. For more detailed information, please feel free to contact us.

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