Normal Lung Organoid Model

As the main organ of the respiratory system, the lungs have a lot of complex biological functions. Lung diseases including chronic obstructive pulmonary disease (COPD), asthma and lung cancer (LC), are difficult to cure, causing great suffering to the patients. In vitro models make many contributions to studying the occurrence and development of lung diseases, however, the representative models recapitulating the structural features of the native lung are still deficient. As a leading biology company, Creative Biolabs has put a lot of effort into the disease area and has developed multi-tissue derived 3D organoids including normal lung organoid models. They have been assessed as high-quality and suitable for preclinical drug discovery projects.

Construction of Normal Lung Organoid Models

At present, the technological challenge of realizing directional differentiation of human pluripotent stem cells (hPSCs) into functionally similar tissue to adult lungs has been overcome. So, normal lung organoids have been constructed through a series of protocols. Among them, the most successful one comprises the following process.

Fig 1. Generation of lung organoids from hPSCs.¹

Advantages of Normal Lung Organoid Models

As its name suggests, organoids are 3D cultures highly similar to in vivo organs, which makes them possess considerable natural advantages over other models and become an attractive choice for exploring disease development and therapeutic biology. Specifically, the main advantages of normal lung organoids can be concluded as follows.

• Firstly, they are composed of multiple cell types that can be found in native organs in vivo, which represents that they are physiologically complex in vitro models.
• Secondly, the structural organization in organoids is alike to the in vivo organ.
• In addition, such organoid models preserve the biological functions of native organs to a large extent.
• Finally, these models faithfully display the histological and genetic features of their derived tissues and are very promising for patient-specific drug trials and proof-of-concept studies on targeted therapy and resistance mechanisms.

Applications of Normal Lung Organoid Models

The emergence of organoids provides new insights into understanding lung biology. To date, numerous reports have confirmed that organoid models are releasing their powerful charm and playing an increasingly significant role in simulating organ evolution and reflecting disease pathobiology, as well as helping drug discovery. Additionally, they can be combined with patient-derived organoids to test drug toxicity. Based on the current positive momentum of organoid development, it seems that normal lung organoid models will be fully exploited in studying the role of specific genes, modeling various aspects of lung development, homeostasis, regeneration and disease. Furthermore, with the help of gene eiditing technology, hPSCs-derived organoids will provide a dynamic platform for translational research.

Related Services

Creative Biolabs has built a robust 3D biology technology platform. Until now, the array of 3D organoid models including normal lung organoids have been available to our global customers. These products are appropriate for conducting the etiology and pathogenesis of disease and developing new treatment strategies. Besides, we have designed a collection of related technical services below for you to choose from. With a professional research team and rich specialist resources, we will be always ready to serve you with our reliable products and trustworthy services. Please don’t hesitate to contact us for more details.

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