Normal Stomach Organoid Model

Stomach cancer is highly prevalent worldwide, and the high mortality rate heavily threatens human health. However, current standard treatments are not effective for all patients due to the failure to consider the heterogeneity of tumors. To enrich limited treatment strategies, developing novelmodels is the most important question to take into consideration first. Through several years of exploration and practice, Creative Biolabs has developed advanced organoid platform for global customers. For stomach cancer research, our normal stomach organoid models are highly customizable to respond to your pluralistic requirements, offering helpful tools for your preclinical drug discovery projects.

Construction of Normal Stomach Organoid Models

Normal stomach organoids are cultured from healthy cells in patient-derived tumor samples. Common construction methods are seeding gastric glands from human resection samples in a basement matrix and culturing them in a special medium containing various growth factors and inhibitors into organoids. In addition, these organoid models can also be constructed through co-culturing operations, for example, the air-liquid interface (ALI) technique.

Fig.1 Differences between scaffold-Matrigel and ALI methods to generate gastric organoids. (Pang, 2022)

Advantages of Normal Stomach Organoid Models

Through the current reports, normal stomach organoid models show marked advantages over current models.

• Preserve growth behavior and morphological phenotype in the ex vivo culture process for up to a year.
• The growth characteristics are not easily influenced or changed by freeze and thaw cycles seemingly.
• The phenotype of normal organoids is reversible, specifically, it can be induced into malignant or normal states, which makes them suitable for studying tumorigenesis.
• Can be employed for drug sensitivity testing and need a shorter time and a cheaper cost than animal models.

Applications of Normal Stomach Organoid Models

In stomach cancer research, normal organoid models offer a novel tool to study phenotypic consequences resulting in tumor development. Besides, they make it possible to quickly test drugs before conducting animal experiments. What needs to be emphasized is that extensive operations can be implemented in these models because they bear non-mutated genomes and potential of expressing a full spectrum of authentic phenotypes. So, a variety of stomach research will benefit from the organoid models, such as infection biology, mucosal immunology, as well as cancer research, and so on.

Related Services

In recent years, Creative Biolabs develops and expands rapidly. Until now, we have established an excellent 3D biology platform. A lot of ex vivo organoid models have been generated and evaluated. Of course, we also configure related technical services listed below for these high-quality organoid products. We are glad to provide you with further information about our related products and services, looking forward to your inquiries at any time.

Related Sections:

• 3D Tumor Organoid Model
• 3D Normal Organoid Model
• Bespoke 3D Organoid Model