3D Biology Based Whole-Exome Sequencing (WES) Service

Creative Biolabs has cutting-edge sequencing systems and trustworthy techniques. We provide our clients all around the world with 3D biology-based whole-exome sequencing services.

What Is 3D Biology?

3D biology model has been a popular research model nowadays and it can more precisely mock the in vivo tissue development or disease occurrence than 2D cell culture, providing abundant research materials for scientists to explore undiscovered information.

3D Biology Based WES

Based on 3D biology, WES can identify the variants found in the coding region of genes that affect protein function. Besides, WES is more concentrated on the exome areas, which can assist achieve better sequencing depth with more high-quality data, increase the sensitivity of the analysis, and simplify the discovery of rare mutations.

A broad categories of 3D cancer models, including patient-derived xenografts, spheroids, and organoids, have been produced for multiple applications. The use of 3D cancer models might enhance preclinical, clinical, and translational research. For example, we can determine how well organoids represent the patient's mutational profile with the use of WES. Both the varied pathophysiology of cancer and possible new biomarkers and treatment targets have been highlighted by this research.

The Procedure of WES

• Firstly, we can extract the DNA from your 3D biology-based aggregates and select only the subset of DNA that encodes proteins by different methods.
• Secondly, we construct the exon library for enriched DNA.
• Finally, sequence the library and analyze the data to discover the mutations we are interested in.

Fig.1 The procedure of whole-exome sequencing. (Creative Biolabs)

With a rigorous scientific criterion for each WES step, Creative Biolabs provides a practical solution with plenty of benefits, such as high-quality data and findings, to help you accomplish your research objectives. Please feel free to get in touch with us about your project for additional information.

3D Models Provided by Creative Biolabs

• 3D Spheroid Model
• Organ-on-a-chip Model
• 3D Ex Vivo Human Tissue Model
• 3D Precision-Cut Tissue Slice Model
• 3D Organoid Model

Related Sections:

• 3D Biology Based Multi-Omics Analysis Services
• 3D Biology Based Immune Response Analysis Services
• 3D Biology Based Target Analysis and Validation Services