Brain Endothelial Cell with Astrocyte and Pericyte Co-Culture Model for Neurological Disorder Drug Discovery and Development

Creative Biolabs provides brain endothelial cells with astrocytes and pericytes co-culture models and related services for global researchers.

Overview of the Human Blood-Brain Barrier (BBB)

BBB is a complex multi-dimensional reticular barrier system made up of cerebral microvascular endothelial cells, pericytes, astrocytes, and many types of neurons, protecting the brain from outside substances. The ability of peripheral substances to reach the central nervous system (CNS) is severely constrained by the tightly welded area between the cerebral capillary endothelial cells, its continuous outer basement membrane, and the terminal foot of glial cells on its outer vessel walls. Most CNS diseases, such as stroke, Alzheimer's disease, and depressive disorder, are associated with BBB barrier dysfunction. Additionally, BBB's barrier function makes it difficult for drugs to enter the CNS and work effectively.

Fig.1 Three-dimensional BBB diagram composed of vascular endothelial cells, vascular smooth machine cells, pericytes, microglia cells, astrocytes, and various neurons. (Wang, 2020)

Brain Endothelial Cells with Astrocytes and Pericytes Co-Culture Model

BBB model is formed by brain endothelial cells (BECs) with astrocytes and pericytes co-culture. BECs act as a major physical barrier to the transit of numerous compounds found in the plasma into the brain. Astrocytes, the most abundant glial cells in the brain, help maintain the unique properties of endothelial cells, thereby contributing to the integrity of the BBB. Pericytes, which are found between BECs and astrocytic and cover capillaries in the brain, can increase transendothelial electrical resistance in the BEC-astrocyte coculture BBB model. Overall, pericytes and astrocyte end-feet make intimate contact with BECs and help to establish, regulate, and maintain the BBB's integrity. Creative Biolabs provides brain endothelial cells with astrocytes and pericytes co-culture models to support your neurological disorder drug discovery and development.

Fig.2 Schematic of BBB-GBM formation in a microfluidic device. (Straehla, 2022)

Features and Applications of Our Model

Creative Biolabs demonstrates significant aptitudes in offering brain endothelial cells with astrocytes and pericytes co-culture models and is committed to making it a valuable preclinical testing platform to speed neurological disorder drug development. If you have related needs, please contact us for more information.

In addition to the brain endothelial cells with astrocytes and pericytes co-culture model, Creative Biolabs also offers other brain cell models. For more details, please click the links below.

• Brain Endothelial Cells Monoculture Model
• Brain Endothelial Cells and Astrocytes Co-Culture Model

Related Sections:

• 3D Spheroid Model for Neurological Disorder Drug Discovery and Development