Current Clamp Assay

Creative Biolabs offers current clamp assays which are commonly used in electrophysiology for electrodiagnosis to help customers to detect membrane potential behavior and measure potential, etc.

What is a Current Clamp?

A current clamp, an electrical device with jaws, is a common technique in electrophysiology. It measures the current in an electrical conductor by clamping it without touching the wire directly or disconnecting it in order to insert a probe. Current clamp recording is a type of intracellular recording that entails continuously injecting positive or negative current (as "square" d.c. pulses) into the cell while measuring the voltage difference across the cell's membrane.

Applications of Current Clamp Assay

Fig.1 Sample depiction of the current changes.¹

Advantages of Recording in Current Clamp

1. The recording method has no impact on the membrane potential, and the experiment requires fewer changes as a result.
2. The amplifier records the voltage produced by the cell on its own or in response to stimulation, and the membrane potential is free to change.
3. This recording of a neuron firing as a result of being depolarized by current injection is made using a whole-cell current clamp.

Creative Biolabs offers professional current clamp assays to assist you in carrying out electrophysiological research. Please contact us to inform us of your requirements.

With professional model building knowledge and an excellent service team, Creative Biolabs promises to provide high quality experimental modes that cover a variety of types at the cell, organ, and tissue levels to meet all your research needs. The models we can provide include but are not limited to:

• 3D Spheroid Model
• Organ-on-a-chip Model
• 3D Ex Vivo Human Tissue Model
• Precision-Cut Tissue Slice Model

Related Sections:

• Electrophysiology Assays