3D Biology Based Tumor Killing Assays

Creative Biolabs offers 3D in vitro model-based tumor killing detection that enables automated detection and quantitative analysis of tumors using technologies engineered to mimic in vivo tissue and image processing algorithms. It extracts relevant killing features by generalizing real tumors and accurately classifies and localizes against these features.

3D Biology-Based Tumor Killing Detection Steps

1. Modeling and drug treatment. In vitro culture of isolated tumor cells and exposure to different killing factors using proven tumor model data.
2. Imaging acquisition. The morphology, size, and metabolism of the tumor are observed by medical imaging devices (CT, MRI, etc.), and the obtained 3D tumor model images are pre-processed, including noise removal, contrast enhancement, and image brightness adjustment. The tumor-related features are extracted using image processing algorithms, and the most distinguishing features are selected.
3. Functional testing. Determination of specific functional, metabolic, and invasive indicators of tumor cells in models killing stimulated.
4. Molecular biology testing. Detecting changes in molecular markers or gene levels in killed 3D in vitro tumor models.

Applications

• Understanding the sensitivity and responsiveness of tumor cells to means.
• Evaluate the effectiveness of kill strategies for timely correction and optimization.
• Simulates positioning and operational assistance planning prior to tumor intervention to improve the safety and accuracy of treatment.

Fig. 1 Diagram of building the 3D tumor platform and detecting kills.1

Multiple Cell-mediated 3D Biology Based Tumor Killing Assays

Detection of multiple cell-mediated tumor-killing effects can be achieved by flow cytometry to distinguish the killing activity of different cell types and by immunohistochemistry to detect the presence and distribution of tumor cells.

3D biology-based tumor-killing assay at Creative Biolabs places tumor cells in a highly in vivo-like culture system and enables efficient quantitative detection and reproducible analysis of tumor-killing models through the application of biological assays and image processing analysis. For further information, please feel free to contact us.

Related Sections:

• 3D Biology Based Multi-Omics Analysis Services
• 3D Biology Based Immune Response Analysis Services
• 3D Biology Based Target Analysis and Validation Services