As part of innate immunity, NK cells (natural killer cells) have multiple receptors that recognize abnormal cells and can autonomously detect and remove abnormal cells in the body, such as cancer cells or virally infected cells. To more accurately test the pathway and extent of NK cell-mediated tumor killing, Creative Biolabs offers a 3D biology platform-based assay for NK cell-mediated killing.
Fig. 1 Quantification of luciferase-based CAR-NK cell killing on 3D models.1
As the traditional two-dimensional cell co-culture system is not representative of the pathological features, the 3D ex vivo model better approximates the complexity of the physiological system, so that the results observed in this model are more likely to be replicated in humans.
The 3D biology model also allows us to study cell-cell interactions, which is important when studying how NK cells kill tumor cells, offering the possibility of developing more effective cancer treatments.
Creative Biolabs offers the 3D bionic ex vivo model assay platforms described above, providing promising services for predicting specific responses to therapy through advanced therapeutic combinations involving NK cells. Please contact us to discuss your needs.
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