PDX-Derived Bladder Cancer Organoid Model

Bladder cancer (BC) is a common malignant tumor, whose therapeutic progress is hindered mainly owing to lacking effective preclinical research models. Creative Biolabs pays close attention to this disease and has been devoted to becoming your trustworthy partner for the research on BC and the exploration of potential therapeutic strategies.

Shortcomings of Common Models

Conventional 2D cell culture makes contributions to research on BC, but it is defective because of its high homogeneity and significant difference between in vitro and in vivo tumor microenvironment (TME), which prevents us from exploring drug resistance. Afterward, patient-derived xenograft (PDX) models are constructed and offer us the opportunity of simulating primary tumor structure, TME interaction, and tumor heterogeneity. However, it takes a lot of effort not only time but also cost to generate and maintain the PDX model.

Advantages of PDX-derived Bladder Cancer Organoid Models

Overviewing the current existing BC research systems, recently developed PDX-derived BC organoids are well-adapted and quite robust models. Its birth makes up for the above-mentioned shortcomings of common models and brings more exploration horizons for BC research. The advantages of this novel cultural system can be concluded as follows.

• They maintain the aggressive growth ability and histological features of tumors and reproduce the primitive characteristics of original tumors in vivo to the greatest extent.
• The mutational heterogeneity is still well represented in the in vitro environment.
• This research system can accurately reflect the in vivo response of BC to chemical drugs and are a valuable tool for carrying on precision medicine.
• The in vitro culture system obtains stable gene expression ability of the parental tumors in terms of molecular subtype and cellular composition.

Applications

Overall, the PDX-derived BC organoids retain tumor heterogeneity and plasticity and perform an increasingly important role in BC. With advances in bioengineering technology, the PDX-derived organoid model will further expand its applications combined with microfluidic devices, 3D bioprinters, and imaging.

Fig.1 Main applications of bladder cancer organoids. (Creative Biolabs)

Related Services

Creative Biolabs is a global biology company in providing 3D organoid models and related reliable services to researchers in the life science field. We pursue the most advanced science and technology so as to provide the highest quality PDX-derived bladder cancer organoid model to help your preclinical drug research achieve great success. Please feel free to contact us to discuss your project for professional assistance.

Related Sections:

• Patient-Derived Organoid (PDO) Model
• PDX-Derived Organoid (PDXO) Tumor Model