Patient-Derived Organoid (PDO) Model

Creative Biolabs is a reliable and reputable biological company committed to providing high-quality products and services for global customers. Our patient-derived organoid (PDO) models are highly customizable to meet your pluralistic requirements, enabling the rapid progress of your preclinical drug discovery projects.

Overview of PDO Models

The PDO model is a miniature 3D tumor cell model cultured in the laboratory, which is isolated from the primary tumor. First of all, the tumor tissue was obtained from the patient's body, cleaned to prevent pollution, and isolated tumor cells. Then, select the appropriate biological material as the 3D culture matrix, and establish the model by simulating the matrix environment of tumor cells. At last, the PDO in vitro model is constructed successfully.

Fig 1. Construction of living PDCO biobank with clinical and genomic information.¹

Advantages of PDO Models

Compared with classic 2D culture models, the PDO in vitro models have unique advantages in some aspects.

• The cost is low, and the culture cycle is short.
• PDOs can still keep genome stability after multiple times of passages.
• The basic features obtained from the in situ tumor tissue are never lost, such as histological, biological, and morphological features and genetic heterogeneity.
• PDO models don’t change their original tumors' genomic and transcriptomic features. Genomic alterations still exist even after undergoing culturing for a few months subsequently.
• PDOs can also be expanded for a long time in vitro but can still keep genome stability, so be suitable for high-through drug screening.

Applications of PDO Models

In new drug development, PDO models have a broad range of applications in the drug development area. PDO models can be used as the optimal in vitro experimental model, shorten the period between the test and clinical trial, reduce drug development costs and risks, provide large amounts of biological data support, to provide a superior platform for new drug research and development.

Fig 2. Challenges and opportunities of the PDCOs model.¹

More PDO Models at Creative Biolabs

To date, we have developed and evaluated a variety of PDO models ex vivo, which are kept accessible to our global customers for studying the pathophysiological mechanism of cancer and developing promising therapeutic strategies. Extensive repositories have also been established to preserve materials expected to be available in various forms in response to urgent needs. Moreover, a series of 3D biology-based assay services are also accessible. We welcome inquiries from interested clients and are always happy to provide further information about the related products and services.

• Patient-derived Liver Cancer Organoid Model
• Patient-derived Lung Cancer Organoid Model
• Patient-derived Breast Cancer Organoid Model
• Patient-derived Gastrointestinal Cancer Organoid Model
• Patient-derived Cervical Cancer Organoid Model
• Patient-derived Ovarian Cancer Organoid Model
• Patient-derived Colorectal Cancer Organoid Model
• Patient-derived Pancreatic Cancer Organoid Model
• Patient-derived Fallopian Tube Cancer Organoid Model

Please contact us in time to learn more about our highly customizable organization models and a detailed quote.

Related Sections:

• 3D Tumor Organoid Model
• 3D Normal Organoid Model
• Bespoke 3D Organoid Model