PDX-Derived Organoid (PDXO) Tumor Model

Creative Biolabs is a reliable and reputable biological company committed to providing high-quality products and services for customers all over the world. Our PDX-derived organoid (PDXO) tumor models are highly customizable to meet your pluralistic requirements, ensuring the rapid progress of your projects.

Overview of PDXO Tumor Models

The PDXO tumor model falls into an in vitro model that is constructed from the tumor tissues of the patient-derived xenograft (PDX) models. Usually, tumor tissues are firstly dissociated into small fragments. Then, they need to be washed and filtered to remove the debris. Next, we collect and suspend the cell clusters in the basement membrane extract (BME) solution. Finally, the mixture is transferred into a culture dish and cultured in a CO₂ incubator to generate organoids for subsequent drug discovery applications.

Fig.1 The PDXO tumor models. (Creative Biolabs)

Advantages of PDXO Tumor Models

PDXOs offer significant advantages over standard 3D models and in vivo PDX models.

• PDXO cultures keep heterogeneity and phenotypes after undergoing long-term cultivation.
• PDXOs have the ability to preserve the genomic characteristics of original tumors and display aggressive growth dynamics.
• Such models highly reproduce molecular and histopathological characteristics of the tumor in vivo.
• PDXO models are amenable to high-through drug screening and offer a relatively accurate prediction of drug possible responses in vivo.
• PDXOs can be established from large amounts of accessible PDXs easily and rapidly.

Applications of PDXO Tumor Models

Since its birth, the PDXO tumor model has been widely recognized by the academic circle owing to its strong applicability to various occasions. As a special ex vivo organoid model from PDX models, it’s a more satisfying tool in the drug discovery area of malignant tumors. Given a collection of advantages over traditional models, it is promising to become a mainstream technology applied to diverse research purposes in the future.

Fig.2 Applications of PDXO tumor models. (Creative Biolabs)

Our Hot PDXO Tumor Models

Creative Biolabs has constructed and verified a series of PDXO models, which are suitable for studying the pathophysiological mechanism of tumors and exploring promising therapeutic strategies. Most products are in stock to respond to your emergency needs.

Related Services

In addition to diverse models, we also provide you with intimate preclinical research services based on 3D biology and assays. We welcome your various inquiries whether technology or the product itself and are always happy to provide detailed information about our products and services. Please contact us at any time to learn more about our highly customizable organization models and related services.

Related Sections:

• 3D Tumor Organoid Model
• 3D Normal Organoid Model
• Bespoke 3D Organoid Model