Breast cancer (BC) is a serious threat to female health, and there is no specific medicine for its treatment currently. Creative Biolabs has developed PDX-derived breast cancer organoid models for the exploration of potential therapeutic strategies against breast cancer.
Commonly used cell models are passaged in a 2D medium and fail to normally describe the structure and microenvironment of tissues in vivo. In addition, the cell lines often undergo genetic drift and lose the heterogeneity of the original tumor. By contrast, as a supplement to the in vitro 2D model, PDX models perform well in most cases. But the expensive cost and long period are hard to accept. Besides, its adaptability to the high-through screening of such models is not quite satisfying.
Recently developed organoid models offer new horizons to model and analyze patient samples, and are increasingly becoming a novel tool to further characterize the molecular features of BC. Compared to traditional cell and animal models, their advantages in many aspects are overwhelming.
Breast cancer organoids including PDX-derived BC organoids have been applied in large-scale drug screening, evaluating the drug sensitivity and validating disease-causing genomic variations as a complementary model. This technology will exist for a long time and boost the scientific advances in revealing the evolution mechanism of tumors and discovering new therapeutic drugs.
Fig.1 Main applications of breast cancer organoids. (Creative Biolabs)
As a global biology company, Creative Biolabs is sensitive to advanced technology and committed to providing 3D organoid models and reliable services listed below to customers worldwide in the breast cancer field. At Creative Biolabs, we pursue the most advanced science and take every customer and your project seriously. Whenever you need it, we will provide the highest quality PDX-derived breast cancer organoid model to facilitate your preclinical drug discovery projects. Please contact us at any time for any professional technical support you want.