PDX-Derived Cervical Cancer Organoid Model

Cervical cancer is one of the most common malignant tumors of the female reproductive system. Although the use of preventive vaccines for coping with human papillomavirus (HPV) infection is spreading all over the world, the incidence and mortality haven’t been controlled fully. Therefore, it is still necessary to seek new treatment strategies and verify them on a representative preclinical model. At Creative Bio labs, our professional research and development team continuously study new 3D ex vivo models such as PDX-derived cervical cancer organoids to serve our customers worldwide.

Shortcomings of Common Models

For conducting cancer research, 2D cell cultures are usually considered the gold standard of in vitro models. But they are incapable of mimicking the tumor microenvironment (TME) and may cause a great difference in drug resistance between in vivo and in vitro. Patient-derived xenograft (PDX) animal models can create a more similar tissue microenvironment than cell systems, becoming a highlight of modern oncology research. Nevertheless, their ability to predict drug response is relatively limited. Moreover, the use of such models introduces a series of concerns, such as high costs, high hands-on time requirements and ethical issues.

Advantages of PDX-derived Cervical Cancer Organoid Models

In recent years, tumor organoids based on tumor explants are gradually constructed from various organs, which are termed PDX-derived organoids (PDXOs). The cervical cancer PDXO is still in its infancy and has limited research data. But in essence, the PDXO generated by sampling tissues from mice is still a special form of the patient-derived organoid (PDO) model. So, it makes sense that the PDX-derived cervical cancer organoid may copy almost all the strengths of PDO models. We agree that their representative advantages are not just restricted to the following.

• Enable the capture of a semblable TME to the parental tumor within in vitro settings.
• Retain the biochemical and physical features of the original tumor and tumor heterogeneity.
• Obtain the potential of carrying on personalized treatment assessments.
• Be capable of constantly passaging multiple times in vitro and suitable for bio-banking and expedited drug evaluation.

Potential Applications

In the regard of treatment status of cervical cancer, there are still unmet clinical demands in the disease field. With the rapid development of biological technology, the application perspectives of PDXO models will be further emphasized in personalized cervical cancer therapy.

Fig.1 Perspectives for application of 3D models in personalized cervical cancer therapy. (Kutle, 2023)

Related Services

Creative Biolabs is a biology company with a wide range of businesses, which keeps track of various frontier 3D biology technology. Over the decades, we focused on providing highly customizable 3D organoid products to customers worldwide, and have won much approval and praise. At Creative Biolabs, we aim to accelerate your project via high-quality 3D organoid models like the PDX-derived cervical cancer organoid and reliable technical services listed below. Please feel free to contact us for more information or any support you want.

Related Sections:

• Patient-Derived Organoid (PDO) Model
• PDX-Derived Organoid (PDXO) Tumor Model