PDX-Derived Mixed Mullerian Cancer Organoid Model

Malignant mixed Mullerian cancer, also called carcinosarcoma (CS), is a rare and aggressive type of ovarian cancer. The disease that is derived from epithelial cells has little research data about the efficacy of chemotherapy drugs, which is very unfavorable for its treatment. Thus, it’s still necessary to seek novel treatment strategies. At Creative Biolabs, we are concerned about the research needs in preclinical drug discovery and have built a collection of 3D organoid models including patient-derived xenograft   (PDX)-derived mixed Mullerian cancer organoid model to serve global customers.

Construction of PDX-derived Mixed Mullerian Cancer Organoid Models

Usually, the generation process of PDX-derived organoids is semblable to patient-derived organoids. The main difference is that the former starts its culture from the tumor tissue of the xenograft models. PDX-derived organoids (PDXOs) including the ones derived from mixed Mullerian cancer generally follow the construction protocol as shown in Fig.1.

Fig.1 PDX-derived tumor cell culture (Idrisova, 2022)

Advantages of PDX-derived Mixed Mullerian Cancer Organoid Models

Although the relevant research on mixed Mullerian cancer is very limited, we can obtain some inspirations from other PDXO research reports and conclude their potential advantages.

• Keep normal epithelial cells propagating for a long time in an in vitro physiological setting.
• Be able to capture the heterogeneity of original tumors.
• Easy to conduct genome edits and provide a helpful tool for high-throughput screening.
• Be suitable to develop individualized medicine due to the ability to reflect patient responses.

Applications

With its popularity around the world, the organoid system gradually starts to attract the eyes of mixed Mullerian cancer researchers. Given the high utility of organoid technology, we believe it will be extensively applied in a variety of research fields, such as pathogenesis and developmental biology, tissue regeneration, drug screening, mechanism of drug resistance, and individualized treatment.

Related Services

Creative Biolabs is a reputable biology company that has paid much attention to the 3D biology area for many years. Through continuous development, we have built an amount of ex vivo physiological models including 3D organoid models. In addition to high-customized in vitro models, we also provide 3D biology-based supporting services listed below to help your project smoother. With high rigorousness and professionalism, we fully understand every customer and expect to become your first choice. Please contact us in time to obtain more information or any support you want.

Related Sections:

• Patient-Derived Organoid (PDO) Model
• PDX-Derived Organoid (PDXO) Tumor Model