PDX-Derived Ovarian Cancer Organoid Model

Due to its insidious onset, ovarian cancer is diagnosed at an advanced stage and causes a high case fatality rate. So new effective treatment plans need further research. With a professional scientific team, Creative Biolabs has developed a series of new 3D models including PDX-derived ovarian cancer organoid model to serve our worldwide customers.

Shortcomings of Common Models

Although 2D cell cultures such as Hela cell lines offer a lot of convenience in maintenance and operation, they can’t respond well to in vivo drug response because of genetic mutation and the loss of tumor cellular components. In addition, owing to the model establishment relying on immunodeficient mice, the genetically engineered mouse models (GEMMs) and patient-derived xenograft (PDX) models have the same shortcoming of the lack of comparable immune tumor microenvironment (TME).

Advantages of PDX-derived Ovarian Cancer Organoid Models

PDX-derived organoid (PDXO) models are constructed from subcutaneous tumors removed from the PDX model and have been applied in ovarian cancer research at present. Overall, the ovarian cancer PDXO models are superior to common models in several ways.

• Firstly, they preserve the genetic material of the primary tumor and are able to truly mirror the patient's response to the drug.
• Secondly, the morphological characteristics are greatly retained and also prove that it is a potential preclinical drug screening model.
• Furthermore, the ovarian cancer PDXO models are easy to operate gene editing subsequently.
• Finally, such PDXO models complement PDX models and serve as a helpful tool to improve the drug sensitivity test.

Applications

Nowadays, PDXO model has been used as a relatively novel tool for tumor research. Reliable results have found a close relation between patient-derived organoids (PDOs) and the patient's response, which offers a option for individualized treatment of patients. Besides, PDXOs have been further applied in exploring the TME and additional experiments studying PDOs under the electron microscope. Similarity, the ovarian cancer PDXO models are promising to be used in many kinds of cancer research.

Fig.1 Main applications of PDX-derived ovarian cancer organoids. (Creative Biolabs)

Related Services

Since its establishment, Creative Biolabs is keen on exploring advanced biology technology and keeping track of the latest research progress in the 3D biology field. Currently, we have successfully established an advanced 3D biology platform to accelerate the development of preclinical drug discovery. As always, we are full of energy and enthusiasm to serve every customer until you’re fully satisfied, and are doing our utmost to be your preferred partner. We ensure our first-rate PDX-derived ovarian cancer organoid products and related services listed below are accessible to you so as to promote your preclinical drug research more smoothly. Please contact us at any time to obtain more information.

Related Sections:

• Patient-Derived Organoid (PDO) Model
• PDX-Derived Organoid (PDXO) Tumor Model