PDX-Derived Thyroid Cancer Organoid Model

The thyroid gland is responsible for regulating energy metabolism and growth by secreting and governing the thyroid hormone (TH). However, it is also an organ with a high risk of malignancy. In the past, due to a lack of reliable models, research on thyroid cancer has been progressing slowly. With rich experience in establishing 3D ex vivo models, Creative Biolabs has developed multiple PDX-derived organoid (PDXO) tumor models including PDX-derived thyroid cancer orgaboid model for customers across the world.

Shortcomings of Common Models

For a long time, the 2D culture system and animal models are the most commonly used models for thyroid research. Regrettably, the former is incapable of representing cell-cell and cell-extracellular matrix (ECM) interactions owing to the planar growth on the culture dish, which fails to reflect the complex physiological process between cells. In addition, the latter can not reproduce the regulatory mechanisms and cell interactions occurring in human tissue due to distinct cell structure and species physiology differences. Thus, it is urgent and necessary to establish a new reliable model that can compensate for these shortcomings.

Advantages of PDX-derived Thyroid Cancer Organoid Models

Organoids possess the ability to self-organize themselves into a 3D structure, which makes them special. Patient-derived tumor xenograft (PDX) organoids are constructed from the tumor tissue of PDX models. Their advantages, by contrast, are very obvious than the above-mentioned models.

• Offer the possibility of observing the close relationship and active interaction between different cell types in vitro.
• Capture the mutation profile and key structural features of the original tumor, enabling them to be suitable models for representing living tumors for related research.
• Retain tumor heterogeneity successfully, which is of significance for thyroid cancer studies.
• Can be maintained by long-term passages in vitro and can remain mutation genes unchanged.
• Dynamically adapt to various operation conditions and easy to combine with other techniques for multiple application purposes.
• Alleviate the ethical issues caused by animal models.

Fig 1. The advantages of PDX over other models.^1,3

Applications

Until now, thyroid organoid models have gradually become a popular platform for studying living organs in vitro. Despite not being used widely, PDX-derived thyroid cancer organoids have shown endless possibilities for potential applications in understanding the tumorigenesis mechanisms, screening anti-tumor drugs, and establishing the biobank for personalized medicine.

Fig 2. Applications of organoids and PDOs for drug discovery and precision medicine.^2,3

Related Services

Creative Biolabs has rich expert resources and a professional technical team, which will assist you in overcoming various challenges on your scientific journey. At present, our ex vivo physiological model network has contained a collection of 3D organoid models, which are highly customizable and suitable for performing various tumor research. Apart from high-quality organoid models, we also provide the following technical services relevant to organoids. We will always take your project seriously and aim to obtain your satisfaction and praise. Please contact us in time to obtain more information for any support you want.

Related Sections:

• Patient-Derived Organoid (PDO) Model
• PDX-Derived Organoid (PDXO) Tumor Model