Creative Biolabs is one of the leading custom antibody generation and development providers. We specialize in the generation of antibodies against a wide range of targets for R&D, diagnostic, and therapeutic applications. Currently, we have launched a series of in vitro diagnostic (IVD) antibody development services targeting numerous diagnostic biomarkers of human diseases. Here, we focus on the atrial natriuretic peptide (ANP) as a marker of sepsis.
Atrial Natriuretic Peptide (ANP)
Atrial natriuretic peptide (ANP) is a peptide hormone which reduces an expanded extracellular fluid (ECF) volume by increasing renal sodium excretion. ANP is synthesized and secreted by cardiac muscle cells in the walls of the atria in the heart. These cells contain volume receptors which respond to increased stretching of the atrial wall due to increased atrial blood volume. ANP acts on the kidney to increase sodium and water excretion (natriuresis). Reduction of blood volume by ANP can result in secondary effects such as reduction of extracellular fluid (ECF) volume (edema), improved cardiac ejection fraction with resultantly improved organ perfusion, decreased blood pressure, and increased serum potassium. These effects may be blunted or negated by various counter-regulatory mechanisms operating concurrently on each of these secondary effects.
Fragments derived from the ANP precursor, including the signal peptide, N-terminal pro-ANP, and ANP, have been detected in human blood. ANP and related peptides are used as biomarkers for cardiovascular diseases such as stroke, coronary artery disease, myocardial infarction and heart failure.
Fig. 1 The functions of atrial natriuretic peptide (ANP).1,2
ANP Marker of Sepsis Infections
Members of the natriuretic peptide family have established markers of congestive heart failure. Defending against hypertension and salt and water retention, they antagonize the renin-angiotensin-aldosterone system, including effects on renal tubule sodium reabsorption, vascular tone, and cell growth. ANP is predominantly produced in the atrium of the heart and comprises 98% of natriuretic peptides in the circulation. Recently, both ANP and pro-ANP have attracted interest as new markers in the field of sepsis.The salutary cardiovascular effects of natriuretic peptides suggest that ANP may have a pathophysiological significance in the cardiac dysfunction of septic patients. It may serve as useful laboratory markers to indicate myocardial dysfunction and may help to differentiate between survivors and non-survivors of severe sepsis.
IVD Antibody Development Services Targeting ANP Marker
Antibodies are core elements for antibody-based immunoassays for detecting and quantifying antigens of interest in all kinds of samples such as the serum, urine, and tissue preparations. IVD antibodies are extensively used for disease screening, prognosis, and therapeutic monitoring. With our versatile IVD platform, Creative Biolabs is proud to develop novel anti-ANP antibody from scratch to commercial IVD kit (we can also start with provided antibody candidates). If you are interested in our IVD antibody discovery services, please feel free to contact us for more information and a detailed quote.
References
For Research Use Only.
