As a pioneer in the antibody field, Creative Biolabs is professional in the discovery and development of in vitro diagnostic (IVD) antibodies. Our years of experience, vast expertise and advanced platforms in developing impeccable IVD antibodies make us confident in offering the first-class service of IVD antibody discovery against various markers for sepsis, such as the pentraxin 3 marker.
Pentraxin 3 in Sepsis
Pentraxin 3 (PTX3) belongs to the long pentraxin subfamily within the family of pentraxins. This superfamily has cyclic multimeric structure. As a soluble pattern recognition molecule, PTX3 functions in the innate immune system. Innate immunity is a potentially life-threatening inflammatory response to infection that affords the infected host protection against sepsis. In severe sepsis, accumulation of extracellular histones in the blood results in damage to endothelial cells and causes organ failure. Both in vitro and in vivo, PTX3 protects endothelial cells by causing histones to aggregate against histone-mediated cytotoxicity toward endothelial cells.
Fig. 1 Role of PTX3 in innate immune responses and inflammation.1,2
The Role of Pentraxin 3 in Sepsis
As an acute-phase protein, PTX3 is involved in inflammatory and infectious processes. It has been assessed in studies that the diagnostic and prognostic value of PTX3 in patients with sepsis or septic shock in a medical intensive care unit (ICU). Because of cytotoxic effect on endothelial cells, extracellular histones are considered to be the main cause of septic death, as well as a potential therapeutic target. Based on polyvalent interactions and disorder in the secondary structure, PTX3 interacts with histones to form coaggregates. Additionally, in mouse models of sepsis, the intraperitoneal administration of PTX3 enables the reduction of mortality. It has been suggested that the host protective effects of PTX3 in sepsis are a result of its coaggregation with histones. Trough directed at protecting cells from the toxic effects of extracellular histones, this long pentraxin–specific effect brings a potential basis for the treatment of sepsis.
IVD Antibody Development Services Targeting PTX3 Marker
IVD antibodies have been widely used for disease screening and therapeutic monitoring. As a research partner with years of experience in high-quality antibody development and production, Creative Biolabs offers one-stop solutions from antigen design to antibody pair screening. Besides, we also offer diagnostic immunoassay development services, including feasibility analysis, assay design, assay protocol establishment, assay optimization, and kit production.
Our services can be tailor-designed to adapt to specific project specifications. Please do not hesitate to contact us for more details.
References
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