As a pioneer in antibody discovery and development, Creative Biolabs is professional in the generation of in vitro diagnostic (IVD) antibodies. Especially, we proudly provide the best quality service of IVD antibody discovery against various markers of different diseases. Here, we introduce our IVD antibody development services against cholesterol esters.
General Introduction of Cholesterol Esters
Cholesteryl esters are both the intracellular storage form and intravascular transport form of cholesterol. Cholesteryl esters exist in liquid states, crystal, and liquid crystal. Cholesterol (cholest-5-en-3β-ol) is a member of polycyclic compounds families, referred to sterols, and expressed abundantly by far in animal tissues. Cholesterol plays a vital role in cell signaling, transport processes and nerve conduction in mammals. Cholesterol esters also play an essential role in the normal functioning of cells not only as a cell membrane constituent but also as a precursor of steroid hormones and other key metabolites including vitamin D and bile acids. The physical state of cholesteryl esters at physiologic temperatures may be a determinant of their pathogenicity.
Fig. 1 2D Structure of cholesteryl esters.
The Role of Cholesterol Esters in Sepsis
In a related research, total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein, and triglyceride levels were compared between sepsis cases and controls. Cholesterol, apolipoprotein, phospholipid and CETP concentrations were monitored in the case group. According to reports, it suggested that HDL cholesterol may have a protective effect against sepsis and the magnitude reduction of lipoprotein level during the acute-phase response may be associated with the severity and mortality of sepsis. HDL cholesterol may have a protective effect against sepsis. The reduction of plasma CETP may result in mortality. The study has been shown that lipoproteins and CETP levels were associated with severe sepsis in hospitalized patients.
IVD Antibody Development Services for Cholesteryl Esters
Antibodies are core elements for antibody-based immunoassays for detecting and quantifying antigens of interest in different samples such as the serum, urine, tissue preparations, and so on. At Creative Biolabs, we offer a full range of antibody development, antigen & antibody conjugation, and IVD kit development services to clients across the globe. We develop antibodies that can be applied for different immunoassay formats, including ELISAs, lateral flow immunochromatographic assays, western blot, and flow cytometry.
Creative Biolabs has extensive experience and mature technology platforms in generating and developing IVD antibodies. If you are interested in discovering novel IVD antibody, please do not hesitate to contact us for more details.
For Research Use Only.
