As a world-leading service provider of antibody development and generation, Creative Biolabs is ready to provide a whole series of biomarker-specific in vitro diagnostic (IVD) antibody development services. A team of experienced scientists focused on antibody development are pleased to assist you in your project in a timely and cost-effective manner. Here, we introduce our IVD antibody development services targeting macrophage inflammatory protein 1 (MIP-1).
Macrophage Inflammatory Protein 1
Macrophage Inflammatory Proteins (MIP) belong to the family of chemotactic cytokines referred to chemokines. MIP has two major forms in humans MIP-1α and MIP-1β, also termed CCL3 and CCL4 respectively. While stimulated with bacterial endotoxin, both of them are major factors produced by macrophages. There are two important findings recently that led to a renewed interest in MIP-1 proteins, highly related ligands and activators of CC chemokine receptors (mainly CCR1, 3, and 5): (1) the effector chemokines CCL3 and CCL4, which are produced and secreted by activated macrophages to attract other pro-inflammatory cells, are also crucial in recruiting themselves to sites of inflammation; and (2) CCL3 can potently inhibit the macrophages uptake of HIV-1 via CCR5 ligation.
Fig.1 The function of MIP-1 in immune cell recruitment.1
The Role of MIP-1 in Sepsis
It is reported that MIP-1 proteins are key players in the pathogenesis of many inflammatory conditions and diseases including sepsis, asthma, granuloma formation, wound healing, arthritis, multiple sclerosis (murine EAE model), pneumonia, and psoriasis. In septic patients, levels of MIP-1alpha and MIP-1beta were detected elevated within 24 h of sepsis. MIP-1alpha and MIP-1beta increase during acute inflammation but are not associated with fever in endotoxemic humans during cyclooxygenase blockade. MIP-1 plays a key role in the induction and modulation of inflammatory responses, i.e. in the context of autoimmune reactions and host defense responses. In addition, MIP-1 proteins regulate various aspects of tissue homeostasis. MIP-1 also has important physiological functions such as in thymic and stem cell development, angiogenesis, and tumor biology, which are discussed in excellent recent reviews.
IVD Antibody Development Services Targeting MIP-1 Marker
IVD antibodies have been widely used for disease screening and therapeutic monitoring. As a research partner with years of experience in high-quality antibody development and production, Creative Biolabs offers one-stop solutions from antigen design to antibody pair screening. Besides, we also offer diagnostic immunoassay development services, including feasibility analysis, assay design, assay protocol establishment, assay optimization, and kit production.
Our services can be tailor-designed to adapt to specific project specifications. If you are interested in our services, please do not hesitate to contact us for more details.
Reference
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