As a world-leading service provider of antibody development and generation, Creative Biolabs is ready to provide a whole series of biomarker-specific in vitro diagnostic (IVD) antibody development services. A team of experienced scientists focused on antibody development are pleased to assist you in your project in a timely and cost-effective manner. Here, we introduce our IVD antibody development services targeting L-Selectin marker.
L-Selectin
L-selectin is a cell adhesion molecule found on lymphocytes and the preimplantation embryo. It is a member of the selectin family of proteins, which recognize sialylated carbohydrate groups. L-selectin serves as a "homing receptor" for lymphocytes entering the secondary lymphoid tissue through the high endothelial venules. Ligands presented on endothelial cells will bind to lymphocytes expressing L-selectin, slow down lymphocytes trafficking through the blood, and facilitating entry into a secondary lymphoid organ at the time. The receptor is usually present on the cell surface of T cells. Naive T lymphocytes that have not encountered their specific antigens need to enter the secondary lymph nodes to encounter their antigens. Central memory T lymphocytes encounter antigens and express L-selectin to localize in secondary lymphoid organs. Here, they are ready to proliferate when they encounter the antigen again. Effector memory T-lymphocytes do not express L-selectin because they circulate peripherally and have immediate effector function when antigen is encountered.
Fig. 1 Structure of the SELL protein.1
L-Selectin Marker of Sepsis Infections
L-Selectin is an adhesion molecule that is shed from the surface of lymphocytes and granulocytes upon activation. Soluble L-selectin in the plasma can thus reflect immune activation and is elevated in several pathological states. Clinical studies have shown that during systemic inflammatory reactions, L-selectin is shed and detected at elevated levels in the plasma. It is found that the greatest survival was among septic adults that presented with the highest levels of sL-selectin, and similar findings were made in another study focused on children. In addition, in an in vitro fluid shear flow model, exogenously added sL-selectin inhibited leukocyte rolling and firm adhesion to the endothelium in a dose-dependent manner, presumably by competing with cell surface L-selectin for binding of endothelial ligands.
IVD Antibody Development Services Targeting L-Selectin Marker
IVD antibodies have been commonly used in immunodiagnostic kits for the disease diagnosis and prognosis. Creative Biolabs has built a versatile IVD platform to provide custom biomarker-specific IVD antibody development services to global clients. In addition, Creative Biolabs provides one-stop diagnostic immunoassay development services, including feasibility analysis, assay design, assay protocol establishment, validation, and production. Along with over a decade of rich experience in providing excellent custom services for IVD antibody discovery, our services can totally meet your special requirements.
If you are interested in our services, please do not hesitate to contact us for more details.
Reference
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