As a leading CRO of antibody generation and development, Creative Biolabs offers application-specific antibody development services to global clients. With experienced scientists and advanced technology, we have established a series of high-quality in vitro diagnostic (IVD) antibody development services against biomarkers of different diseases. Here, we introduce our IVD antibody development services for IL-1β marker.
Introduction of IL-1β
IL-1β, a member of the 11 IL-1 families, is the best characterized and most studied in this family. As a potent pro-inflammatory cytokine, IL-1β plays a crucial role in host-defense responses to infection and injury. It is produced and secreted by a variety of cell types, including monocytes and macrophages. It is produced as an inactive 31 kDa precursor, termed pro-IL-1β, in response to molecular motifs carried by pathogens called ‘pathogen-associated molecular patterns’ (PAMPs). PAMPs act through pattern recognition receptors (PRRs) on macrophages to regulate pathways that control gene expression. Induction of pro-IL-1β expression is generally referred to as a priming step and is an inefficient secretion stimulus. The primed cell must now encounter a further PAMP, or DAMP (danger associated molecular pattern, endogenous molecules released from dead cells) to induce the processing and secretion of an active IL-1β molecule.
Fig.1 IL-1β secretion. (Lopez-Castejon, G., 2011)
IL-1β in Sepsis
Also known as catabolin, IL-1β is a member of the interleukin-1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase-1. IL-1β is an important mediator of the inflammatory response and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The role of IL-1β in sepsis has not been extensively studied. It has been reported that after simultaneous measurement of 17cytokines during the first seven days after admission of patients with sepsis, IL-1β exhibited persistent increases in those who died, suggesting that IL-1β may play a role in sepsis.
In recent years, IVD technology is undergoing rapid development. IVD antibodies have been widely used in immunodiagnostic tools to aid in the diagnosis of various diseases, conditions, and infections. With years of experience and advanced technology, Creative Biolabs is able to provide a full range of high-quality and cost-effective biomarker-specific antibody development services. Especially, we help develop novel anti-IL-1β antibodies for your IVD projects. Having completed a number of IVD antibody generation and development projects, Creative Biolabs is confident to offer you the best products and services to promote your project a success.
For more detailed information, please feel free to contact us or directly send us an inquiry.
Reference
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